The aqueous crude extracts of P. amarus and E. hirta were administered to thirty eight-week old sexually mature male albino to determine the effects of these extracts on the male reproductive organs of these animals. The results from this study revealed that the aqueous crude extracts of P. amarus and E. hirta caused varying degrees of testicular degeneration as well as reduction in the mean seminiferous tubular diameter (STD) in the treated rats. It thus shows that the aqueous crude extracts of P. amarus and E. hirta have potentially deleterious effects on the testes and accessory organs of rats. Great caution should therefore be exercised in the use of these plants for medicinal purpose.