Cytomegalic inclusion disease is a relatively uncommon systemic disease characterized by transplacental infectibility, and manifests itself in a new born infant as hepatosplenomegaly, thrombocytopenia, jaundice and various neurological symptoms. Except intracranial calcifications, osseous lesions in long bone are very rare and have not been previously reported in Korea. Authors report a case of 8 week-old infant with congenital cytomegalic inclusion disease who presented with osteomalacia, pathologic fracture of the both fibula, and characteristic ricketic physeal and metaphyseal changes.