Osteoporosis is a state of decreased mass per unit volume of normally mineralized bone and mostly common skeletal disorder. Aged person over 65 years old, usually complains back pain and spine deformity due to the osteoporosis. The pathomechanism of osteoporosis is still unknown but the change of bone remodelling and turnover is known as main pathophysiology. Present approach to the treatment of osteoporosis depends on the prevention of bone loss and treatment of established disease, There are many empirical approachs, such as drug therapy, exercise, and nutrition. Many authors have reported the treatment of osteoporosis but they are quite few reports about the preventive treatment of age-related changes on normal persons. Authors have studied continuously for one year on the effect on osteoporosis of calcitonin, 1-α( OH) D3, and placebo and then evaluated these effects with parameters such as Dual Photon Absorptiometry, X-ray, osteocalcin, and serum study. The results in comparison with the preventive effect for decrease and improvement effect of the bone density are as follows;1. Bone density change in normal aged person shows 1.3% decreased average rate at the femur neck and 1.4% at lumbar spine. 2. It appears markedly much lower back pain in those persons treated with the calcitonin and 1-α (OH) D3 for one month and especially, the treatment effect of calcitonin is superior. 3. Saville's index shows no significant change in all three groups. 4. Serum parameters shows no significant change during medication. 5. Osteocalcin, representing the bone turnover is decreased in all three groups and there is no treatment effect on the bone turnover rate. 6. Bone density, measured by the dual photon absorptiometry is decreased at the femur neck, but the group of calcitonin treatment shows much lower decrese-speed than other groups. At the lumbar spine, it is increased in the both calcitonin and 1-α(OH) D3 treatment groups. On the contrary, it shows decrease in the control group. Calcitonin shows mueh more increased view than 1-α(OH) D3.