Seventy-five sciatic nerves of New Zealand white rabbit were divided into 5 groupsdirect apposition (no gap), 5mm, 10mm, 15mm, and 20mm gap were used. And group were subdivided into A (no other treatment), B (topical steroid), C group (end-to-end anastomosis with silicone tube). At 3, 6, 12 weeks, nerve conduction velocity, gross observation, light and electron microscopic observation were done. The successful regeneration of a multifascicular peripheral nerve through a silicone tube across a gap of 15mm in the rabbit sciatic nerve was observed. The importance of the distal nerve as a source of traget-derived neuronotrophic factors necessary for the successful regeneration of the proximal regenerating nerve is emphasized. A simplified research model for further investigation into and manipulation of the biological processes of nerve regenration is mandatory. The potential clinical utilization of silicone tube in the management of peripheral nerve injuries required further study.