Segmental fracture of the femoral shaft is known as an unusual injury, usually caused by a severe force and associated with marked damage to the soft tissues and is difficult to treat. Most authors have agreed that intramedullary nailing is the treatment of choice for this uncommon injury. Twenty one cases with the segmental fractures of the fremur shaft were reviewd, which were treated at the Department of Orthopedic Surgery. Soonchung University Hospital from Jan. 1986 to Dec. 1989. The resulsts are 1. Average operative time was shorter with Ender nailing than with other methods. 2. Period of fracture union was 34 weeks in Ender nailing, 34.7 weeks in interlocking nailing and 52.8 weeks in plate fixation. So average union period was 40.5 weeks in all cases. 3. High incidence of complication was shown in the cases treated with plate fixation. 4. Lower incidence of complication was noted in the cases with treated Ender nailing and interlocking nailing. From above results, we conclude that flexible IM nailing or interlocking nailing seems to be a favorable method for the treatment of segmental fracture of the femoral shaft.