Essential osteolysis is a rare, progressive, slow and bone-resorptive disease that mainly involves carpal bone, metacarpal bone, tarsal bone, metatarsal bone and elbow joint. Authors had recently experienced one case of “essential osteolysis” that had involved the bilateral carpal, metacarpal, bilateral tarsal, metatarsal bone, elbow and ankle joint without associated renal insufficiency, hypertension and significant familial history.