Hematogenous metastases to the limb skeletal muscles are extremely rare. Better understanding of the mechanisms resulting in the relative resistance of skeletal muscle to metastases could have bearing on therapeutic interventions for prevention of metastases. One patient with squamous cell cancer of lung and metastasis to the calf muscles are presented. Skeletal metastases may be presented as painful masses in the distal skeletel muscles. Subcutaneous and osseous metastases which are more frequent must be excluded by careful physical examination, bone scan, and X-rays. Magnetic resonance imaging (MRI) can confirm the location of the tumor within the fascial planes of skeletal muscles and may help in the accurate delineation of the radiation portal. The tumor can be diagnosed and more common causes, such as hematoma or abscess, can be excluded by thin needle aspiration with cytologic examination. The authors have experienced a case of skeletal muscle metastasis from lung cancer, affecting the calf muscle.