Liposarcoma is one of the most common soft tissue sarcomas which frequently occurs in the 4th decade of life. It occurs frequently in extremities or retroperitoneal region in order. Sixteen patients out of 21 patients were followed-up more than 1 year, from April 1985 to May 1992. Ten were males and 6 females. Their average age was 49 years. The locations of tumor were 7 in thigh, each 2 in thoracic wall, upper arm and lower leg, and each one case in forearm, neck and palm. According to the AJC classification stage IA were 3 cases, IB 5, IIB 1, IIIB 2, IVA 1 and IVB 4 cases.Pathologically, 9 cases showed myxoid, mixed (inflammatory+ well differentiated, and pleomorphic mixed with myxoid) 2, well-differentiated 1, pleomorphic 2 and unidentified 2. The treatment principle was the combination of surgery, radiotherapy and/or chemotherapy. Twelve cases took resection of tumor with more than wide margin. Palliative operation was done for 2 cases. Adjuvant chemotherapy only was done for 3 patients. Adjuvant radiotherapy only was done for 6 cases. Six cases received radiotherapy and/or chemotherapy. One case received surgical treatment only. Four cases showed distant metastasis at first visit. Duration of follow up was 46 months in average. Twelve cases were disease free, alive with disease 2 and died of disease (lung metastasis) 2 at final follow up. Five year actual survival except multiple metastasis at first visit was 100 percent.