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Joon Sung Kim, Byung-Wook Kim
Abstract
Despite recent advances in endoscopic techniques and acid-suppressive therapies, non-variceal upper gastrointestinal bleeding (NVUGIB) is still associated with significant morbidity and mortality. The increased use of dual antiplatelet agents and oral anticoagulants has complicated the management of NVUGIB. Physicians often have to decide on when to discontinue and resume these medications in patients with NVUGIB. However, clinical data regarding the resumption of antiplatelets and anticoagulants are still minimal. Here, we report and summarize the key recommendations made in the recent Asia-Pacific guidelines regarding management of antithrombotics in patients with NVUGIB.
Figures and Tables
Table 1
Asia-Pacific Working Group Consensus Statements on Patients with NVUGIB
Each statement was then assessed for level of evidence by the following criteria: (a) high level of evidence; further research is very unlikely to change our confidence in the estimate of effect, (b) moderate level of evidence; further research is likely to have an important impact on our confidence in the estimate of effect and may change the recommendation and (c) low level of evidence; further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
NVUGIB, non-variceal upper gastrointestinal bleeding; DOAC, direct oral anticoagulant.
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