L-plastin: Structure, Regulation, and Roles in Cancer Invasion and in Macrophages

Hwa-Jung Kim; Hwang-Ho Lee

doi:10.4167/jbv.2018.48.4.175

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Kim and Lee: L-plastin: Structure, Regulation, and Roles in Cancer Invasion and in Macrophages

Research Update (Minireview)

Journal of Bacteriology and Virology 2018; 48(4): 175-180.

Published online: 31 December 2018

DOI: https://doi.org/10.4167/jbv.2018.48.4.175

L-plastin: Structure, Regulation, and Roles in Cancer Invasion and in Macrophages

Hwa-Jung Kim¹, Hwang-Ho Lee²

¹Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea.

²Department of Microbiology and Immunology, Medical School, Chonbuk National University, Jeonju, Korea.

Corresponding: Hwang-Ho Lee. Department of Microbiology and Immunology, Medical School, Chonbuk National University, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea. Phone: +82-63-270-3070, Fax: +82-63-270-3070, hwangho@jbnu.ac.kr

Received 21 December 2018 Revised 21 December 2018 Accepted 24 December 2018

The Korean Society for Microbiology and The Korean Society of Virology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

The cytoskeleton consists of 3 filamentous components: intermediate filaments, microtubules, and actin filaments. Actin filaments continuously assemble and disassemble far out of equilibrium to adapt cells in response to external stimuli. Actin filaments organization and dynamic are controlled by a multitude of actin-binding proteins including actin-bundling proteins. L-plastin, expressed abundantly in lymphocytes and monocytes, is an actin-bundling protein that roles in immune defense and in metastatic invasion of cancer cells. The actin-bundling activity of L-plastin is regulated not only by intracellular calcium concentration, but by phosphorylation of Ser5. The actin-bundling activity of L-pastin decreases by increased calcium concentration but is promoted by phosphorylation of Ser5. The morphology changes and motility of cells requires continuous remodeling of actin filaments which demands the sensitive nature of L-plastin to Ca²⁺-signal, phosphorylation of Ser5, and probably additional regulation. This review briefly describes the structure and regulation of L-plastin, and roles for L-plastin in cancer invasion and in macrophages.

Keywords: L-plastin, Calcium, Phosphorylation

ACKNOWLEDGEMENT

This work was partly supported by the Chonbuk National University Medical School Alumni Association Fund.

Notes

No potential conflict of interest relevant to this article was reported.

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