Journal List > Korean J Pediatr Gastroenterol Nutr > v.2(1) > 1110618

Korean J Pediatr Gastroenterol Nutr. 1999 Mar;2(1):40-45. Korean.
Published online Mar 31, 1999.
Copyright © 1999 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Seroepidemiology of Hepatitis A and Hepatitis B in Korean Children
Jae Sung Ko, Sun Hwan Bae, Ju Young Chung, June Key Chung and Jeong Kee Seo
Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea.
Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea.


The aim of this study is to investigate the seroepidemiology of hepatitis A and hepatitis B in Korean children.


801 children aged 6 to 12 years were enrolled. IgG antibody to hepatitis A virus (anti-HAV), hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs), and IgG antibody to HBc (anti-HBc) were measured by radioimmunoassay.


Of the 801 children, the seroprevalence of anti-HAV was 0%. Three (0.4%) were seropositive for HBsAg. The seroprevalence of anti-HBs was 61.8%. Two (0.4%) of 495 anti-HBs positive subjects were positive for anti-HBc. Of the 801 children, 658 (82.1%) had received hepatitis B vaccination.


Since natural anti-HAV is not acquired in the childhood, the outbreak of hepatitis A is possible in adolescents and young adults. The decrease in seroprevalence of HBsAg and the increase in seroprevalence of anti-HBs might result from hepatitis B vaccination program in childhood.

Keywords: Hepatitis A; Hepatitis B; Seroepidemiology; Children