Journal List > Korean J Pediatr Gastroenterol Nutr > v.2(2) > 1110611

Korean J Pediatr Gastroenterol Nutr. 1999 Sep;2(2):233-239. Korean.
Published online Sep 30, 1999.
Copyright © 1999 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
A Case of Acrodermatitis Enteropathica Associated with CMV Hepatitis
Kwang Yeol Kim, Jae Ock Park and Sang Mann Shin
Depatment of Pediatrics, College of Medicine, Soonchunhyang University, Seoul, Korea.

Acrodermatitis enteropethica (AE) is a rare autosomal recessive disorder of zinc absorption leading to chronic diarrhea and characteristic skin lesion. The term is also applied to any acquired zinc deficiency state resulting in the same clinical pictures. We experienced one case of AE in 1 month old male infant who had bacterial enterocolitis. The skin around mouth, anus, eyes, ears, hands and legs became reddish, vesicular and eczematoid. Serum zinc level was decreased to 51.4 microgram/dL (N=70~150). Endoscopic finding revealed pale gastric mucosa and villous atrophy of small intestine. Biopsy finding of small intestine showed no villi due to mucosal atrophy. On 13 day of admission jaundice with DIC were noted and AST & ALT were elevated to 110 & 36.8 IU/L, respectively. Diarrhea was improved but jaundice and liver function were not recovered until discharge from hospital. After discharge when the patient was 4 months of age serum bilirubin and AST/ALT had not been normalized. CMV shell vial culture of urine and CMV Ig G antibody were positive. So intravenous ganciclovir injection of 7.5 mg/kg, two times a day for 2 weeks and then 10 mg/kg/day for 3 months was done from 4 to 6 months of age. No virus was found in the urine and AST & ALT were normalized at 2 months after stopping ganciclovir treatment.

Keywords: Acrodermatitis enteropathica; CMV Hepatitis