Journal List > Korean J Pediatr Gastroenterol Nutr > v.2(1) > 1110594

Korean J Pediatr Gastroenterol Nutr. 1999 Mar;2(1):109-115. Korean.
Published online Mar 31, 1999.
Copyright © 1999 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
A Case of Vertical Transmission of Hepatitis C Virus in an Infant of a Mother Who had Hepatitis C during Pregnancy
Sang Hyun Oh, Kuk Hwan Kim, Eun Seok Yang, Sang Kee Park and Kyung Rye Moon
Department of Pediatrics, Chosun University Medicine College, Kwangju, Korea.

Hepatitis C virus (HCV) has been identified as an important cause of posttransfusion hepatitis, but vertical transmission of chronic infected HCV RNA positive mothers has been documented in some cases. The reports of the risk of perinatal infection have been widely varied in the literature. The authors experienced one case of vertical transmission of HCV in an infant of a mother who had hepatitis C during pregnancy. At admission, HCV RNA (+), Ig G anti HCV (+) and Ig M anti HCV (+) were found in the mother Also at admission, HCV RNA (+), Ig G anti HCV (+), Ig M anti HCV (+), elevation of liver aminotransferase level and hepatosplenomegaly on ultrasonography were found in the baby on day 31. HCV RNA (-), Ig M anti HVC (-) and normal of liver aminotransferase level were noted on day 250 in the serum of the infant. We used reverse transcriptase polymerase chain reaction (RT-PCR) technique to find a very small amount of HCV RNA in the serum. All the findings suggest vertical transmission of HCV RNA from mother to infant during 3rd trimester of pregnancy.

Keywords: Hepatitis C virus; Vertical transmission; Reverse transcriptase polymerase chain reaction