Journal List > Korean J Pediatr Gastroenterol Nutr > v.3(2) > 1110544

Korean J Pediatr Gastroenterol Nutr. 2000 Sep;3(2):151-159. Korean.
Published online Sep 30, 2000.  https://doi.org/10.5223/kjpgn.2000.3.2.151
Copyright © 2000 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Clinical and Histopathologic Features and Their Correlations in Children with Nodular Duodenitis
Hann Tchah, and Sung Suk Paeng1
Department of Pediatrics, Seoul Red Cross Hospital, Seoul, Korea.
1Department of Pathology, Seoul Red Cross Hospital, Seoul, Korea.
Abstract

PURPOSE

Recently, a wide application of gastrofiberscopy in the pediatric group have revealed that nodular duodenitis is not an uncommon disease in children and is suspected to be associated with H. pylori infection. The aim of this retrospective study was to investigate the clinical and histopathologic features in children with nodular duodenitis, and to assess the correlations beween both.

METHODS

During a period of 5 years (Jan. 1995∼Dec. 1999), we investigated clinical, endoscopic and histopathologic features of 39 consecutive patients diagnosed as having nodular duodenitis at Pediatric department of Seoul Red Cross Hospital. In 35 children with nodular duodenitis endoscopic biopsy specimens were stained with Hematoxylin & Eosin and Giemsa's stain, and were graded according to the criteria outlined by Triadafilopoulos, Whitehead et al., and Prieto et al.. Statistical analyses were performed with Graph PAD InStat.

RESULTS

The prevalence rate of nodular duodenitis was 17.1% and the most frequent chief complaint was abdominal pain (69.2%). Endoscopically grade 1 was the most common (45.7%) and nodular gastritis was coexistent in 28.3%. The most common histology of the duodenum was grade 2 (54.3%), and the most common histologic score of the stomach was 2 (42.9%). H. pylori was found in the duodenum in 37.1%, and in the stomach in 31.4%. The correlation coefficient between the endoscopic grade and the histologic grade of nodular duodenitis was 0.3983 (p=0.0178). And the correlation coefficient between the histologic grade and the grade of H. pylori colonization in the duodenum was 0.5154 (p=0.0018).

CONCLUSION

There was significant correlation between the endoscopic grade and the histologic grade of nodular duodenitis, and was also significant correlation between the histologic grade and the grade of H. pylori colonization in the duodenum. Therfore H. pylori infection should be regarded as an etiologic factor of nodular duodenitis.

Keywords: Nodular duodenitis; H. pylori infection; Child