Journal List > J Lipid Atheroscler > v.7(2) > 1110541

Lim, Kwon, and Kim: The Model for Evaluation on Blood Flow of Functional Food in Human Intervention Study

Abstract

The prevalence of atherothrombotic disease continues to rise, presenting an increasing number of challenges to modern society and creating interest in functional foods. Platelet activation, adhesion, and aggregation at vascular endothelial disruption sites are key events in atherothrombotic disease. Physiological challenges such as hyperlipidemia, obesity, and cigarette smoking are associated with vascular changes underlying platelet aggregation and inflammatory processes. However, it is difficult to determine the beneficial response of functional foods in healthy subjects. To address this problem, challenge models and high-risk models related to smokers, obesity, and dyslipidemia are proposed as sensitive measures to evaluate the effects of functional foods in healthy subjects. In this review, we construct a model to evaluate the effects of functional food such as natural products on blood flow based on a human intervention study.

Figures and Tables

Fig. 1

Main process and events involved in phenotypic flexibility of atherothrombosis.NO; nitric oxide, LDL; low-density lipoprotein.

jla-7-88-g001

Notes

Funding This study was supported by the Ministry of Science, ICT, and Future Planning through the National Research Foundation of Korea (NRF-2012M3A9C4048761).

Conflict to Interest The authors have no conflicts of interest to declare.

References

1. Ueshima H, Sekikawa A, Miura K, Turin TC, Takashima N, Kita Y, et al. Cardiovascular disease and risk factors in Asia: a selected review. Circulation. 2008; 118:2702–2709.
2. Libby P, Okamoto Y, Rocha VZ, Folco E. Inflammation in atherosclerosis: transition from theory to practice. Circ J. 2010; 74:213–220.
crossref
3. Jackson SP. Arterial thrombosis--insidious, unpredictable and deadly. Nat Med. 2011; 17:1423–1436.
crossref
4. Li Z, Delaney MK, O'Brien KA, Du X. Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol. 2010; 30:2341–2349.
crossref
5. Ferroni P, Basili S, Falco A, Davì G. Oxidant stress and platelet activation in hypercholesterolemia. Antioxid Redox Signal. 2004; 6:747–756.
crossref
6. Cuevas AM, Guasch V, Castillo O, Irribarra V, Mizon C, San Martin A, et al. A high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers. Lipids. 2000; 35:143–148.
crossref
7. Ceriello A, Bortolotti N, Motz E, Lizzio S, Catone B, Assaloni R, et al. Red wine protects diabetic patients from meal-induced oxidative stress and thrombosis activation: a pleasant approach to the prevention of cardiovascular disease in diabetes. Eur J Clin Invest. 2001; 31:322–328.
crossref
8. Heptinstall S, May J, Fox S, Kwik-Uribe C, Zhao L. Cocoa flavanols and platelet and leukocyte function: recent in vitro and ex vivo studies in healthy adults. J Cardiovasc Pharmacol. 2006; 47 Suppl 2:S197–S205.
crossref
9. Kardinaal AF, van Erk MJ, Dutman AE, Stroeve JH, van de Steeg E, Bijlsma S, et al. Quantifying phenotypic flexibility as the response to a high-fat challenge test in different states of metabolic health. FASEB J. 2015; 29:4600–4613.
crossref
10. Broos K, Feys HB, De Meyer SF, Vanhoorelbeke K, Deckmyn H. Platelets at work in primary hemostasis. Blood Rev. 2011; 25:155–167.
crossref
11. Gross PL, Weitz JI. New antithrombotic drugs. Clin Pharmacol Ther. 2009; 86:139–146.
crossref
12. Steinhubl SR, Moliterno DJ. The role of the platelet in the pathogenesis of atherothrombosis. Am J Cardiovasc Drugs. 2005; 5:399–408.
crossref
13. Wopereis S, Wolvers D, van Erk M, Gribnau M, Kremer B, van Dorsten FA, et al. Assessment of inflammatory resilience in healthy subjects using dietary lipid and glucose challenges. BMC Med Genomics. 2013; 6:44.
crossref
14. Esser D, Oosterink E, op 't Roodt J, Henry RM, Stehouwer CD, Müller M, et al. Vascular and inflammatory high fat meal responses in young healthy men; a discriminative role of IL-8 observed in a randomized trial. PLoS One. 2013; 8:e53474.
crossref
15. van Mierlo LA, Zock PL, van der Knaap HC, Draijer R. Grape polyphenols do not affect vascular function in healthy men. J Nutr. 2010; 140:1769–1773.
crossref
16. Gregersen NT, Bitz C, Krog-Mikkelsen I, Hels O, Kovacs EM, Rycroft JA, et al. Effect of moderate intakes of different tea catechins and caffeine on acute measures of energy metabolism under sedentary conditions. Br J Nutr. 2009; 102:1187–1194.
crossref
17. Zwaka TP, Hombach V, Torzewski J. C-reactive protein-mediated low density lipoprotein uptake by macrophages: implications for atherosclerosis. Circulation. 2001; 103:1194–1197.
crossref
18. Fichtlscherer S, Breuer S, Heeschen C, Dimmeler S, Zeiher AM. Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery disease. J Am Coll Cardiol. 2004; 44:44–49.
crossref
19. Roche HM, Gibney MJ. The impact of postprandial lipemia in accelerating atherothrombosis. J Cardiovasc Risk. 2000; 7:317–324.
crossref
20. Mertens A, Holvoet P. Oxidized LDL and HDL: antagonists in atherothrombosis. FASEB J. 2001; 15:2073–2084.
crossref
21. Thorin E, Hamilton CA, Dominiczak MH, Reid JL. Chronic exposure of cultured bovine endothelial cells to oxidized LDL abolishes prostacyclin release. Arterioscler Thromb. 1994; 14:453–459.
crossref
22. Pedreño J, Hurt-Camejo E, Wiklund O, Badimón L, Masana L. Platelet function in patients with familial hypertriglyceridemia: evidence that platelet reactivity is modulated by apolipoprotein E content of very-low-density lipoprotein particles. Metabolism. 2000; 49:942–949.
crossref
23. Stalenhoef AF, de Graaf J. Association of fasting and nonfasting serum triglycerides with cardiovascular disease and the role of remnant-like lipoproteins and small dense LDL. Curr Opin Lipidol. 2008; 19:355–361.
crossref
24. Sinzinger H, Berent R. Platelet function in the postprandial period. Thromb J. 2012; 10:19.
crossref
25. Coelho RC, Hermsdorff HH, Gomide RS, Alves RD, Bressan J. Orange juice with a high-fat meal prolongs postprandial lipemia in apparently healthy overweight/obese women. Arch Endocrinol Metab. 2017; 61:263–268.
crossref
26. Hodgson JM, Burke V, Puddey IB. Acute effects of tea on fasting and postprandial vascular function and blood pressure in humans. J Hypertens. 2005; 23:47–54.
crossref
27. Ono-Moore KD, Snodgrass RG, Huang S, Singh S, Freytag TL, Burnett DJ, et al. Postprandial inflammatory responses and free fatty acids in plasma of adults who consumed a moderately high-fat breakfast with and without blueberry powder in a randomized placebo-controlled trial. J Nutr. 2016; 146:1411–1419.
crossref
28. Basu A, Betts NM, Leyva MJ, Fu D, Aston CE, Lyons TJ. Acute cocoa supplementation increases postprandial HDL cholesterol and insulin in obese adults with type 2 diabetes after consumption of a high-fat breakfast. J Nutr. 2015; 145:2325–2332.
crossref
29. Lim Y, Lee KW, Kim JY, Kwon O. A beverage of Asiatic plantain extracts alleviated postprandial oxidative stress in overweight hyperlipidemic subjects challenged with a high-fat meal: a preliminary study. Nutr Res. 2013; 33:704–710.
crossref
30. Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol. 2008; 8:923–934.
crossref
31. Margioris AN. Fatty acids and postprandial inflammation. Curr Opin Clin Nutr Metab Care. 2009; 12:129–137.
crossref
32. Goldstein RE, Redwood DR, Rosing DR, Beiser GD, Epstein SE. Alterations in the circulatory response to exercise following a meal and their relationship to postprandial angina pectoris. Circulation. 1971; 44:90–100.
crossref
33. Zilversmit DB. Atherogenesis: a postprandial phenomenon. Circulation. 1979; 60:473–485.
crossref
34. Patsch JR, Miesenböck G, Hopferwieser T, Mühlberger V, Knapp E, Dunn JK, et al. Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arterioscler Thromb. 1992; 12:1336–1345.
crossref
35. Tyldum GA, Schjerve IE, Tjønna AE, Kirkeby-Garstad I, Stølen TO, Richardson RS, et al. Endothelial dysfunction induced by post-prandial lipemia: complete protection afforded by high-intensity aerobic interval exercise. J Am Coll Cardiol. 2009; 53:200–206.
36. Newby DE, Wright RA, Labinjoh C, Ludlam CA, Fox KA, Boon NA, et al. Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction. Circulation. 1999; 99:1411–1415.
crossref
37. Ambrose JA, Barua RS. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol. 2004; 43:1731–1737.
38. Jonas MA, Oates JA, Ockene JK, Hennekens CH. Statement on smoking and cardiovascular disease for health care professionals. American Heart Association. Circulation. 1992; 86:1664–1669.
crossref
39. Price JF, Mowbray PI, Lee AJ, Rumley A, Lowe GD, Fowkes FG. Relationship between smoking and cardiovascular risk factors in the development of peripheral arterial disease and coronary artery disease: Edinburgh Artery Study. Eur Heart J. 1999; 20:344–353.
crossref
40. Negri E, Franzosi MG, La Vecchia C, Santoro L, Nobili A, Tognoni G, et al. Tar yield of cigarettes and risk of acute myocardial infarction. BMJ. 1993; 306:1567–1570.
crossref
41. Glantz SA, Parmley WW. Passive smoking and heart disease. Epidemiology, physiology, and biochemistry. Circulation. 1991; 83:1–12.
crossref
42. Law MR, Morris JK, Wald NJ. Environmental tobacco smoke exposure and ischaemic heart disease: an evaluation of the evidence. BMJ. 1997; 315:973–980.
crossref
43. Rhee MY, Na SH, Kim YK, Lee MM, Kim HY. Acute effects of cigarette smoking on arterial stiffness and blood pressure in male smokers with hypertension. Am J Hypertens. 2007; 20:637–641.
crossref
44. Siasos G, Tousoulis D, Kokkou E, Oikonomou E, Kollia ME, Verveniotis A, et al. Favorable effects of concord grape juice on endothelial function and arterial stiffness in healthy smokers. Am J Hypertens. 2014; 27:38–45.
crossref
45. Lanza GA, Spera FR, Villano A, Russo G, Di Franco A, Lamendola P, et al. Effect of smoking on endothelium-independent vasodilatation. Atherosclerosis. 2015; 240:330–332.
crossref
46. Bo S, Ciccone G, Castiglione A, Gambino R, De Michieli F, Villois P, et al. Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial. Curr Med Chem. 2013; 20:1323–1331.
crossref
47. McVeigh GE, Lemay L, Morgan D, Cohn JN. Effects of long-term cigarette smoking on endothelium-dependent responses in humans. Am J Cardiol. 1996; 78:668–672.
crossref
48. Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J, et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation. 1993; 88:2149–2155.
crossref
49. Celermajer DS. Endothelial dysfunction: does it matter? Is it reversible? J Am Coll Cardiol. 1997; 30:325–333.
crossref
50. Winniford MD, Wheelan KR, Kremers MS, Ugolini V, van den Berg E Jr, Niggemann EH, et al. Smoking-induced coronary vasoconstriction in patients with atherosclerotic coronary artery disease: evidence for adrenergically mediated alterations in coronary artery tone. Circulation. 1986; 73:662–667.
crossref
51. Ghazali WS, Romli AC, Mohamed M. Effects of honey supplementation on inflammatory markers among chronic smokers: a randomized controlled trial. BMC Complement Altern Med. 2017; 17:175.
crossref
52. Oyama J, Maeda T, Kouzuma K, Ochiai R, Tokimitsu I, Higuchi Y, et al. Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers. Circ J. 2010; 74:578–588.
crossref
53. Kim Y, Kim KJ, Park SY, Lim Y, Kwon O, Lee JH, et al. Differential responses of endothelial integrity upon the intake of microencapsulated garlic, tomato extract or a mixture: a single-intake, randomized, double-blind, placebo-controlled crossover trial. Food Funct. 2018; 9:5426–5435.
crossref
54. Diez-Roux AV, Nieto FJ, Comstock GW, Howard G, Szklo M. The relationship of active and passive smoking to carotid atherosclerosis 12–14 years later. Prev Med. 1995; 24:48–55.
crossref
55. Howard G, Burke GL, Szklo M, Tell GS, Eckfeldt J, Evans G, et al. Active and passive smoking are associated with increased carotid wall thickness. The Atherosclerosis Risk in Communities Study. Arch Intern Med. 1994; 154:1277–1282.
crossref
56. Korner J, Aronne LJ. Pharmacological approaches to weight reduction: therapeutic targets. J Clin Endocrinol Metab. 2004; 89:2616–2621.
crossref
57. Seo JB, Choe SS, Jeong HW, Park SW, Shin HJ, Choi SM, et al. Anti-obesity effects of Lysimachia foenum-graecum characterized by decreased adipogenesis and regulated lipid metabolism. Exp Mol Med. 2011; 43:205–215.
crossref
58. Grundy SM. Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome. Am J Cardiol. 1998; 81:18B–25B.
crossref
59. Matsubara M, Maruoka S, Katayose S. Decreased plasma adiponectin concentrations in women with dyslipidemia. J Clin Endocrinol Metab. 2002; 87:2764–2769.
crossref
60. Cai Y, Xing G, Shen T, Zhang S, Rao J, Shi R. Effects of 12-week supplementation of Citrus bergamia extracts-based formulation CitriCholess on cholesterol and body weight in older adults with dyslipidemia: a randomized, double-blind, placebo-controlled trial. Lipids Health Dis. 2017; 16:251.
crossref
61. Ruscica M, Pavanello C, Gandini S, Gomaraschi M, Vitali C, Macchi C, et al. Effect of soy on metabolic syndrome and cardiovascular risk factors: a randomized controlled trial. Eur J Nutr. 2018; 57:499–511.
crossref
62. Gulati S, Misra A, Pandey RM. Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians - a randomized controlled, parallel arm study. Lipids Health Dis. 2017; 16:71.
crossref
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