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Korean J Pediatr Gastroenterol Nutr. 2000 Mar;3(1):56-62. Korean.
Published online Mar 31, 2000.  https://doi.org/10.5223/kjpgn.2000.3.1.56
Copyright © 2000 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Serological and Histological Changes after Interferon Alfa Therapy in Children with Chronic Hepatitis B
Jae Sung Ko, Ju Young Chung, Jeong Kee Seo, and Ja Joon Jang1
Department of Pediatrics, Seoul National University Medical School, Seoul, Korea.
1Department of Pathology, Seoul National University Medical School, Seoul, Korea.
Abstract

PURPOSE

The aim of this study was to evaluate the efficacy and histologic changes of interferon-alfa therapy on chronic hepatitis B virus infection in children.

PATIENTS AND METHODS

Thirty five children aged 3~16 years who were seropositive for HBV DNA, HBsAg and HBeAg were enrolled. Interferon-alfa 2a (3.4 MU/m(2)) were given for 6 months. Serologic markers of viral replication was evaluated 1 year after therapy. Post treatment liver biopsy was performed in 18 patients who showed serologic response.

RESULTS

Serum HBeAg and viral DNA became negative in 22 (63%) of treated children at 12 months after therapy. Serum aminotransferase levels normalized in all of the responders and HBsAg became negative in one responder. Horizontal transmission, serum aminotransferase levels more than twice normal, and active inflammation on liver biopsy were predictive factors for response to interferon therapy. Periportal piecemeal necrosis, lobular activity, portal inflammation, fibrosis, and total histologic activity index were reduced in responders.

CONCLUSION

In children with chronic hepatitis B, interferon alfa promotes loss of viral replication and improves aminotransferase. Serologic response is associated with improvement in hepatic histology.

Keywords: Hepatitis B; Interferon Alfa; Child