Journal List > Korean J Pediatr Gastroenterol Nutr > v.3(1) > 1110520

Korean J Pediatr Gastroenterol Nutr. 2000 Mar;3(1):47-55. Korean.
Published online Mar 31, 2000.
Copyright © 2000 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Clinical and Histopathologic Findings on the Abnormal Liver Function Complicated with Kawasaki Disease
Sung Chul Lee, Hann Tchah, Song Yi Na, Hee Sup Kim, Ho JIn Park and Mi Kyeong Shin1
Department of Pediatrics, Seoul Red Cross Hospital, Seoul, Korea.
1Department of Pathology, Seoul Red Cross Hospital, Seoul, Korea.


The aim of this research is to examine the abnormal liver function complicated with Kawasaki disease (KD) and to analyze its clinical characteristics and complications.


Ninty eight cases were diagnosed as having KD, among which thirty four cases had abnormal alanine aminotransferase (ALT) (>30 IU/L). These abnormal ALT cases were evaluated in terms of age and sex distribution, major symptoms, complications, laboratory and histopathologic findings.


Male to female ratio was 2.4 : 1 and most patients (91.2%) were under 5 years of age. Cervical lymphadenopathy was observed in 3 cases (8.8%); and recurred cases were two (5.8%). Average fever duration was 8 days: average length of hospitalization was 9 days; and average recovery period was 13 days. Immediately after admission, positive CRP was observed in 31 cases (91.2%), leukocytosis (>10,000/mm3) in 26 cases (76.0%), thrombocytosis (>450,000/mm3) in 7 cases (20.6%), and anemia (<10 gm/dl) in 7 cases (20.6%), respectively. GB hydrops or cholecystitis were noted in 3 cases (8.8%) abnormal ECG finding in 1 case (2.9%), coronary dilatation or aneurysm in 2 cases (5.9%). Liver biopsy was done in four cases and revealed mild infiltration of lymphocytes on the portal area and mild bile duct proliferations.


The abnormal liver function was noted in 34.7% of KD patients, and subsided all within one month. But the liver function test should be checked closely in patients of the abnormal liver function test complicated with KD despite of its good prognosis.

Keywords: Kawasaki disease; Alanine aminotransferase (ALT); Histopathologic findings