Journal List > Korean J Pediatr Gastroenterol Nutr > v.3(1) > 1110517

Korean J Pediatr Gastroenterol Nutr. 2000 Mar;3(1):23-29. Korean.
Published online Mar 31, 2000.
Copyright © 2000 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
The Effect of 2-Week Dual Therapy with Proton Pump Inhibitor and Amoxicillin in the Eradication of Helicobacter pylori Infection for Treatment of Children with Recurrent Abdominal Pain
Young Mock Lee, Chang Han Lee and Ki Sup Chung
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.


It has recently been recognized that Helicobacter pylori (H. pylori) is an important factor in the pathogenesis of recurrent abdominal pain (RAP) in children. But, the best treatment for H. pylori infection is still unsettled. This study was performed to evaluate the efficacy of 2 weeks dual therapy with proton pump inhibitor (PPI) and amoxicillin for children with H. pylori infection associated with RAP.


Our study included 24 children with RAP who were H. pylori positive assessed by CLO test and histologic examination (silver stain). We used the regimen consisted of PPI (omeprazole, 0.7 mg/kg/day) and amoxicillin (50 mg/kg/day) for 2 weeks to eradicate H. pylori. Eradication of H. pylori was determined 4 weeks after the termination of treatment using the CLO test and histologic examination.


The endoscopic diagnoses of patients were nodular gastritis in 11 cases, superficial gastritis in 7 cases, peptic ulcer in 4 cases and normal finding in 2 cases. H. pylori was eradicated in 12 cases by omeprazole and amoxicillin dual therapy for 2 weeks and the eradication rate was 50%. In 4 of 12 children in whom H. pylori had not been eradicated with that regimen, we successfully eradicated H. pylori with other regimens of which 2 or 3 drugs among omeprazole, amoxicillin, clarithromycin, colloidal bismuth subcitrate (Denol ) and metronidazole were used.


The dual therapy with PPI and amoxicillin for 2 weeks had no clear advantage over other regimens for the eradication of H. pylori infection in children. We concluded that the combination of PPI and amoxicillin for 2 weeks is not so good for H. pylori eradicated other commonly used regimens.

Keywords: Recurrent abdominal pain; Helicobacter pylori; Eradication; Proton Pump Ingibitor; Amoxicillin