Journal List > Korean J Pediatr Gastroenterol Nutr > v.3(1) > 1110513

Korean J Pediatr Gastroenterol Nutr. 2000 Mar;3(1):105-109. Korean.
Published online Mar 31, 2000.
Copyright © 2000 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Hepatocellular Carcinoma Following Vertical Transmission of Hepatitis B Virus in a Child with X-linked Agammaglobulinemia
Jong Gon Oh, Byung Ju Kim,1 Hoon Kook,1 Young Jong Woo,1 Young Youn Choi,1 Jae Sook Ma,1 Tai Ju Hwang,1 and Jong Jin Seo2
Department of Pediatrics, St. Columban's Hospital, Mokpo, Korea.
1Department of Pediatrics, Chonnam National University Medical School, Kwangju, Korea.
2Department of Pediatrics, University of Ulsan College of Medicine, Asan Nedical Center, Seoul, Korea.

X-linked agammaglobulinemia (XLA) is a primary inherited B-cell immunodeficiency. The prevalence of neoplastic disease in patients with XLA is approximatedly 0.7%. The most frequent tumor is lymphoreticular malignancy. We report a case of hepatocellular carcinoma (HCC) in a 13-year-old boy with XLA, after probable maternal transmission of hepatitis B virus. The authors consider that the vertical transmission of hepatitis B virus might play an important role in the development of HCC in a child with XLA who could not eliminate hepatitis B virus effectively.

Keywords: X-linked agammaglobulinemia; Hepatocellular carcinoma; Child; Hepatitis B