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Oh, Kim, Kook, Woo, Choi, Ma, Hwang, and Seo: Hepatocellular Carcinoma Following Vertical Transmission of Hepatitis B Virus in a Child with X-linked Agammaglobulinemia
Case Report

Korean Journal of Pediatric Gastroenterology and Nutrition 2000; 3(1): 105-109.

Published online: 31 March 2000

DOI: https://doi.org/10.5223/kjpgn.2000.3.1.105

Hepatocellular Carcinoma Following Vertical Transmission of Hepatitis B Virus in a Child with X-linked Agammaglobulinemia

Jong Gon Oh, Byung Ju Kim1, Hoon Kook1, Young Jong Woo1, Young Youn Choi1, Jae Sook Ma1, Tai Ju Hwang1, Jong Jin Seo2

Department of Pediatrics, St. Columban's Hospital, Mokpo, Korea.

1Department of Pediatrics, Chonnam National University Medical School, Kwangju, Korea.

2Department of Pediatrics, University of Ulsan College of Medicine, Asan Nedical Center, Seoul, Korea.

Copyright © 2000 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition

Abstract

X-linked agammaglobulinemia (XLA) is a primary inherited B-cell immunodeficiency. The prevalence of neoplastic disease in patients with XLA is approximatedly 0.7%. The most frequent tumor is lymphoreticular malignancy. We report a case of hepatocellular carcinoma (HCC) in a 13-year-old boy with XLA, after probable maternal transmission of hepatitis B virus. The authors consider that the vertical transmission of hepatitis B virus might play an important role in the development of HCC in a child with XLA who could not eliminate hepatitis B virus effectively.

Keywords: X-linked agammaglobulinemia, Hepatocellular carcinoma, Child, Hepatitis B

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