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Korean J Pediatr Gastroenterol Nutr. 2002 Mar;5(1):51-61. Korean.
Published online Mar 31, 2002.  https://doi.org/10.5223/kjpgn.2002.5.1.51
Copyright © 2002 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
The Correlation between Acholic Stool and the Result of Tc99m DISIDA Hepatobiliary Scintigraphy and Biochemical Test in Neonatal Cholestasis
Eun Young Joo, Yeon Mo Ahn, Yong Joo Kim, Soo Ji Moon and Yun Young Choi1
Department of Pediatrics, Hanyang University Hospital, Seoul, Korea.
1Department of Nuclear Medicine, Hanyang University Hospital, Seoul, Korea.
Abstract

PURPOSE

The most common causes of neonatal cholestasis are neonatal hepatitis (NH) and extrahepatic biliary atresia (EHBA). Since neonatal cholestasis presents with variable expression of same pathologic process and has similar clinical, biochemical, and histologic features between EHBA and idiopathic neonatal hepatitis (NH), differential diagnosis is often difficult. We reviewed the differences of clinical characteristics and laboratory data to find out any correlation between the results of Tc99m DISIDA scan and presence of acholic stool.

METHODS

Between June 1993 and January 2001, total 29 infants younger than 4 month-old underwent Tc99m DISIDA scan. Their biochemical tests and clinical course were reviewed retrospectively.

RESULTS

Patients who had negative intestinal activity on Tc99m DISIDA scan showed acholic stool and revealed higher serum direct bilirubin and urine bilirubin level. 18.2% of patients with acholic stool showed intestinal activity on Tc99m DISIDA scan and 81.8% of them did not. All the patients without acholic stool showed positive intestinal activity on Tc99m DISIDA scan. The result of Tc99m DISIDA scan and the presence of acholic stool showed high negative correlation (r :-0.858). Patients with acholic stool and negative intestinal activity on Tc99m DISIDA scan showed higher serum total bilirubin level. Patients without acholic stool and positive intestinal activity on Tc99m DISIDA scan showed higher serum level of ALT.

CONCLUSION

Patients with acholic stool and negative intestinal activity showed high correlation, but 18.2% of patients with acholic stool showed positive intestinal activity. So operative cholangiogram or transcutaneous liver biopsy should be performed for confirmation.

Keywords: Neonatal hepatitis; Extrahepatic biliary atresia; Tc99m DISIDA scan; Acholic stool