Congenital cytomegalovirus (CMV) infections are usually asymptomatic in newborns or may present with rash, hepatosplenomegaly, jaundice, pneumonia, and the development of central nervous system sequelae. Gastrointestinal involvement of congenital CMV infection complicating stricture has been rarely reported, especially in children. We report a case of a 2-month-old body who presented with bloody stool since 3 days of age. Hemotochezia was attributable to CMV colitis with colonic stricture, which was confirmed by histopathology, serologic studies and virus culture. Clinical status of the patient improved with intravenous administration of ganciclovir.