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Korean J Pediatr Gastroenterol Nutr. 2003 Sep;6(2):103-111. Korean.
Published online Sep 30, 2003.  https://doi.org/10.5223/kjpgn.2003.6.2.103
Copyright © 2003 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Helicobacter pylori Infection and Gastroduodenal Pathology in Children with Upper Gastrointestinal Symptoms
Young Ran Yoon, Mi Ryeung Kim, Jae Young Lim, Myoung Bum Choi, Chan Hoo Park, Hyang Ok Woo, Hee Shang Youn, Gyung Hyuck Ko,* Hyung Lyun Kang, Seung Chul Baik, Woo Kon Lee, Myung Je Cho, and Kwang Ho Rhee
Department of Pediatrics, Gyeongsang National University College of Medicine, Jinju, Korea.
***Department of Pathology, Gyeongsang National University College of Medicine, Jinju, Korea.
Department of Microbiology, Gyeongsang National University College of Medicine, Jinju, Korea.
Abstract

PURPOSE

This study was undertaken to evaluate the gastroduodenal pathology and Helicobacter pylori infection in children with upper gastrointestinal symptoms.

METHODS

One hundred and seven pediatric patients with upper gastrointestinal symptoms were undergone endoscopy at the Gyeongsang National University Hospital from June 1990 to April 1991. Histopathologic examination was done by H & E staining of gastric antral biopsy specimen and gastritis was defined according to the Sydney System. Tissue H. pylori status was evaluated with the urease test using Christensen's urea broth and H & E or Warthin-Starry silver staining of gastric antral biopsy specimen. IgG Immunoblotting were also performed to detect specific anti-H. pylori antibody in these patients.

RESULTS

The reasons for endoscopy were recurrent abdominal pain, acute abdominal pain, sallow face, hunger pain, and frequent nausea. Variable degrees of gastric mucosal hyperemia were found in most of the patients. Gastric hemorrhagic spots, gastric ulcer, duodenal ulcer, duodenal erosion, and hemorrhagic duodenitis were rare endoscopic findings. Histologic chronic gastritis was found in 88% of 107 patients. Histologic chronic duodenitis was observed in all 99 patients whose tissue were available. Gastric tissue H. pylori was positive in 57% of 107 patients by one of the ureasetest, H & E staining and Warthin-Starry silver staining. However, gastric tissue H. pylori detection rate was lower in the younger age groups. Anti-H. pylori IgG antibodies were detectable in 96% of 107 patients.

CONCLUSION

Chronic gastroduodenitis and anti-H. pylori IgG antibody were ubiquitous in children with upper gastrointestinal symptoms.

Keywords: Helicobacter pylori; Urease test; Immunoblotting; Gastritis; Child