Journal List > Korean J Pediatr Gastroenterol Nutr > v.8(1) > 1110286

Korean J Pediatr Gastroenterol Nutr. 2005 Mar;8(1):12-20. Korean.
Published online Mar 31, 2005.  https://doi.org/10.5223/kjpgn.2005.8.1.12
Copyright © 2005 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Gastroduodenoscopic Findings and Effect of Therapy of Helicobacter pylori Infection in Children
Kyung Shin Rhee and Jae Ock Park
Department of Pediatrics, College of Medicine, Soonchunhyang University, Bucheon, Korea.
Abstract

PURPOSE

Helicobacter pylori infection is known to be associated with acute or chronic abdominal pain and upper gastrointestinal bleeding in children. This study was performed to analyze the gastroduodenoscopic findings and the efficacy of triple therapy with omeprazole, amoxicillin and clarithromycin between one and two weeks of duration in children with H. pylori infection.

METHODS

We have assessed retrospectively 60 patients presented with acute or chronic abdominal pain or upper gastrointestinal bleeding. H. pylori infection was confirmed by endoscopic biopsy and rapid urease test. Out of 60 patients, 30 patients were treated with a combination of omeprazole, amoxicillin, and clarithromycin for one week, and the other 30 patients were treated for two weeks with the same medication. Efficacy of treatment was assessed 4 weeks after the termination of treatment by using the 13C urea breath test.

RESULTS

The 60 patients with the complaint of diffuse abdominal pain, epigastric pain, vomiting or hematemesis were included in this study. One-week treatment group (group I) consisted of 30 patients (14 male, 16 female) with mean age of 11.6±2.67 years. Two-week treatment group (group II) consisted of 30 patients (11 male, 19 female) with mean age of 10.7±4.17 years. In group I, H pylori were eradicated in 26 out of 30 patients (86.7%). In group II, H. pylori were eradicated in 26 out of 30 children (86.7%). Both groups did 13C urea breath test after 4 weeks after termination of the triple therapy. The eradication rates were same in both groups as 86.7%, 26 out of 30 patients in each group. The results of endoscopy were nodular gastritis 26 (43.3%), erosive gastritis 10 (16.7%), hemorrhagic gastritis 7 (11.7%), gastric ulcer 2 (3.3%) and normal finding 15 (25.0%).

CONCLUSION

In this study, the nodular gastritis was most common endoscopic findings with H. pylori positive patients. The eradication rate of H. pylori with omeprazole, amoxicillin and clarithromycin was 86.7% and it would be highly effective as primary treatment with no significant differences in the eradication rate between one-week and two-week treatment groups. However, we should need more long-term follow-up data.

Keywords: Helicobacter pylori; Triple therapy (omeprazole, amoxicillin and clarithromycin); Gastroduodenoscopic finding; Children