Journal List > Korean J Pediatr Gastroenterol Nutr > v.9(1) > 1110245

Korean J Pediatr Gastroenterol Nutr. 2006 Mar;9(1):23-30. Korean.
Published online Mar 31, 2006.  https://doi.org/10.5223/kjpgn.2006.9.1.23
Copyright © 2006 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Clinical Usefulness of Serum Uric Acid in Gastroenteritis Patients with Dehydration
Jun Ho Song, Myung Wan Jang, Hwang Jae Yoo and Cheol Hong Kim
Department of Pediatrics, Kwandong University College of Medicine, Goyang, Korea.
Abstract

PURPOSE

The estimation of fluid deficit is crucial to the proper management of dehydrated children. Without well-documented serial weights on the same scale, the estimation of any given child's fluid deficit is imprecise and dependent largely on subjective clinical criteria. Despite the abundance of literature on clinical and laboratory evaluation of dehydration, few studies have focused on serum uric acid. So, we examined the usefulness of serum uric acid in gastroenteritis patients with dehydration.

METHODS

Medical records of 90 gastroenteritis patients were retrospectively reviewed. By the body weight loss, we classified patients with mild, moderate, and severe dehydration groups. We studied the relevance of laboratory data (BUN, creatinine, serum bicarbonate, glucose, urine specific gravity, and uric acid) with dehydration.

RESULTS

54 children (60%) were dehydrated mildly, 24 (26%) dehydrated moderately, and 12 (14%) dehydrated severely. Statistically significant differences in BUN, creatinine, serum bicarbonate, glucose, and urine specific gravity could not be observed. But there was significant relationship between uric acid and the degree of dehydration. Data analysis suggested that the level of 7.0 mg/dL is the best cut-off value for predicting the development of moderate or severe dehydration. At this cut-off value, the sensitivity and specificity were 66.6% and 87.1%.

CONCLUSION

Our study supports that the measurement of serum uric acid with traditional scales is useful for predicting the development of dehydration. But, in order to be used as the indicator for proper treatment at an earlier stage, further validation about serum uric acid is necessary.

Keywords: Uric acid; Dehydration; Gastroenteritis