Journal List > Korean J Pediatr Gastroenterol Nutr > v.9(1) > 1110233

Korean J Pediatr Gastroenterol Nutr. 2006 Mar;9(1):14-22. Korean.
Published online Mar 31, 2006.
Copyright © 2006 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Serum Zinc Concentration in Children with Acute Gasrtoenteritis
Hyun Joo Lee,* Hye Won Yom and Jeong Wan Seo
Department of Pediatrics, National Police Hospital, Korea.
*Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea.


To identify factors that influence serum zinc concentrations in children with acute gastroenteritis.


Thirty-two children under 5 years of age (15 boys and 17 girls) were selected randomly among those who visited to an pediatric emergency room of Ehwa Womans University Mokdong Hospital with acute gastroenteritis from May to August 2005. This study estimated the association between serum zinc concentrations and clinical, biochemical variables in patients with acute gastroenteritis.


Serum zinc concentration was lower in febrile patients than afebrile patients with acute gastroenteritis (67.0±25.3 vs 85.5±14.2, p<0.05). It also was lower in patients with positive C-reactive protein (CRP) than those with negative CRP (63.9±25.4 vs 86.7±13.8, p<0.05). Serum zinc concentration was negatively correlated (r=−0.494, p<0.05) with CRP concentration, whereas positively correlated with hematocrit (r=0.370, p<0.05), total protein (r=0.474, p<0.05), and albumin (r=0.636, p<0.05). Twelve patients (37.5%) showed very low serum zinc concentration (<70 µ/dL) without clinical symptoms of deficiency or growth retardation. Frequency of febrile illness or positive CRP is significantly greater in group with zinc <70 µ/dL than the group with zinc > or =70 µ/dL (91.7% vs 55%, p<0.05; 91.7% vs 40%, p<0.05, respectively).


In patients with acute gastroenteritis, serum zinc concentration was influenced by various factors such as fever, CRP, and biochemical factors. For evaluating zinc status in the body. factors.

Keywords: Zinc; Gastroenteritis; Fever; C-reactive protein; Children