Journal List > Korean J Pediatr Gastroenterol Nutr > v.11(1) > 1110176

Korean J Pediatr Gastroenterol Nutr. 2008 Mar;11(1):36-41. Korean.
Published online Mar 31, 2008.  https://doi.org/10.5223/kjpgn.2008.11.1.36
Copyright © 2008 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Clinical Significance of Food-specific IgE Antibody Tests in Food Protein-induced Proctocolitis
Jeong Yoon Song, Yu Na Kang,* Jae Ryong Kim, and Jin Bok Hwang
Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea.
*Department of Pathology, Keimyung University School of Medicine, Daegu, Korea.
Department of Laboratory, Keimyung University School of Medicine, Daegu, Korea.
Abstract

PURPOSE

The aim of this study was to determine the clinical significance of food-specific IgE antibody tests in detecting triggering antigens in food protein-induced proctocolitis (FPIPC).

METHODS

Between February 2006 and May 2007, data from 16 consecutive FPIPC patients that underwent MAST and Uni-CAP tests on initial visits, were reviewed. The endoscopic criterion used for establishing a diagnosis of FPIPC was an increase in the number of eosinophils in the lamina propria (≥60 per 10 high power fields). Offending foods were suspected clinically based on elimination and challenge testing to mother or patient diets with the following five highly allergenic foods: dairy products, eggs, nuts and soybean, fish and shellfish, and wheat and buckwheat. We compared the results of initial MAST or Uni-CAP tests with clinically suspected offending foods.

RESULTS

For the 16 FPIPC patients, MAST tests showed positive results in 2 patients (12.5%), and Uni-CAP tests showed positive results in 3 patients (18.8%). Through clinical elimination and challenge, the 33 offending foods were identified: 7 fish and shellfish (21.2%), 6 eggs (18.2%), 6 wheat and buckwheat (18.2%), 4 dairy products (12.1%), 3 soybean (9.1%), 3 pork (9.1%), 2 nuts (6.1%), 1 beef (3.0%), and 1 mushroom (3.0%). Clinically suspected offending foods and MAST and Uni-CAP test results were found to be correlated in 1 patient (6.7%) each.

CONCLUSION

Food specific IgE antibody tests are inappropriate for predicting offending foods in FPIPC. Clinical food elimination and challenge testing provide useful means of detecting offending foods.

Keywords: Food protein-induced proctocolitis; Offending food; Food specific IgE antibody test; MAST; Uni-CAP; Elimination; Challenge