Journal List > Korean J Pediatr Gastroenterol Nutr > v.11(2) > 1110120

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Hong, Lee, Lee, Shin, Ko, and Seo: Trace Elements Deficiency and the Diagnostic Usefulness of Hair Mineral Analysis in Children with Chronic Gastrointestinal Disease
Original Article

Korean Journal of Pediatric Gastroenterology and Nutrition 2008; 11(2): 122-129.

Published online: 30 September 2008

DOI: https://doi.org/10.5223/kjpgn.2008.11.2.122

Trace Elements Deficiency and the Diagnostic Usefulness of Hair Mineral Analysis in Children with Chronic Gastrointestinal Disease

Jeana Hong, Jung Hwa Lee*, Ran Lee†, Jee Youn Shin, Jae Sung Ko, Jeong Kee Seo

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

*Gyeonggi Provincial Medical Center Pocheon Hostpial, Korea.

†Department of Pediatrics, Konkuk University School of Medicine, Seoul, Korea.

jkseo@snu.ac.kr

Copyright © 2008 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition

Abstract

PURPOSE

Patients with chronic gastrointestinal disease are at risk for trace element deficiency due to impaired absorption and gastrointestinal loss. The aim of this study was to evaluate the trace element status of patients with gastrointestinal disease by blood and hair analysis, and to determine the usefulness of hair mineral analysis for diagnosing trace element deficiency not detected by a blood test.

METHODS

An analysis of hair minerals was performed and compared with blood mineral analysis in 13 patients with chronic gastrointestinal disease. The concentration of each element in the hair and blood was compared in the subgroups based on parenteral nutritional support or clinical symptoms.

RESULTS

Almost all patients had trace element deficiency. The trace elements deficient in the blood or hair analysis included zinc, selenium and copper. The hair zinc concentration was significantly lower in the group receiving parenteral nutritional support. The hair selenium concentration was statistically associated with the clinical symptoms of hair loss, brittle hair and loss of hair pigmentation.

CONCLUSION

The results of this study suggest that patients with chronic gastrointestinal disease should receive adequate zinc and selenium replacement to avoid trace element deficiency especially when treated with long-term parenteral nutrition. Hair mineral analysis is useful as a complementary tool for the detection of a trace element deficiency.

Keywords: Chronic gastrointestinal disease, Trace element deficiency, Hair analysis

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