Effect of Intense Regulated Pulse Light on Thickness of Tear Film Lipid Layer and Dry Eye Syndrome

Tae Young Gil; Gi Hyun Bae; Joo Young Kwag; Joo Hyun; Jin Seok Choi; Kyu Hong Pak; Sung Kun Chung

doi:10.3341/jkos.2018.59.12.1103

Journal List > J Korean Ophthalmol Soc > v.59(12) > 1109295

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Gil, Bae, Kwag, Hyun, Choi, Pak, and Chung: Effect of Intense Regulated Pulse Light on Thickness of Tear Film Lipid Layer and Dry Eye Syndrome

Original Article

Journal of the Korean Ophthalmological Society 2018; 59(12): 1103-1107.

Published online: 17 December 2018

DOI: https://doi.org/10.3341/jkos.2018.59.12.1103

Effect of Intense Regulated Pulse Light on Thickness of Tear Film Lipid Layer and Dry Eye Syndrome

Tae Young Gil, MD¹, Gi Hyun Bae, MD¹, Joo Young Kwag, MD², Joo Hyun, MD², Jin Seok Choi, MD, PhD², Kyu Hong Pak, MD², Sung Kun Chung, MD, PhD²

¹Department of Ophthalmology, SahmYook Medical Center, Seoul, Korea.

²Saevit Eye Hospital, Goyang, Korea.

Address reprint requests to Sung Kun Chung, MD, PhD. Department of Ophthalmology, Saevit Eye Hospital, #1065 Jungang-ro, Ilsandong-gu, Goyang 10447, Korea. Tel: 82-31-900-7700, Fax: 82-31-900-7777, eyekun@gmail.com

Received 26 July 2018 Revised 10 September 2018 Accepted 27 November 2018

The Korean Ophthalmological Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To evaluate the clinical effect of intense regulated pulse light (IRPL) and changes in tear film thickness in dry eye patients.

Methods

A retrospective study was conducted on 25 patients with Meibomian gland dysfunction who had subjective dry eye discomfort and whose tear film break-up time (TBUT) was < 10 seconds. All patients were treated with IRPL three times on days 1, 15, and 45. TBUT, Schirmer 1 test results, cornea staining score with fluorescein, ocular surface disease index (OSDI), and lipid layer thickness were measured and compared before and after the procedure.

Results

TBUT was significantly increased from 3.7 ± 1.2 s to 4.4 ± 2.1 s after IRPL (p = 0.03). Schirmer 1 test and cornea staining scores changed significantly (p < 0.01 and p = 0.01, respectively). OSDI also showed a statistically significant improvement from 39.5 ± 17.5 points to 30.4 ± 18.7 points (p = 0.01). However, no significant difference in lipid layer thickness was observed (p = 0.49).

Conclusions

IRPL is an effective treatment modality to improve TBUT, Schirmer 1 test scores, cornea staining scores, and subjective dry eye symptoms.

Keywords: Dry eye syndrome, Intense pulse light (IPL), Intense regulated pulse light (IRPL), Lipid layer thickness (LLT), Lipiview

Figures and Tables

Figure 1

Photograph of the intense regulated pulse light device (E-Eye; E-SWIN, Houdan, France).

Figure 2

Intense regulated pulse light treatment zone. The hand piece treats the highlighted areas for a total of 5 spots on each side of the face, and is then repeated in a second pass. Proper ocular protection is used.

Table 1

Results of three times of IRPL treatment

Values are presented as mean ± standard deviation unless otherwise indicated.

IRPL = intense regulated pulse light; tBUT = tear break-up time; sec = second; LLT = lipid layer thickness; OSDI = ocular surface disease index.

^*Paired t-test.

Notes

^{Conflicts of Interest} The authors have no conflicts to disclose.

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