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Ji Hyen Lee1, 2, *
, Han Wool Kim1, 2, *, Kyung-Hyo Kim1, 2
, Han Wool Kim1, 2, *, Kyung-Hyo Kim1, 2
Abstract
Purpose
The number of dengue fever cases is rising due to increasing overseas travel. Vaccination makes severe dengue fever in seronegative individuals after vaccination when they exposure to wild-type dengue virus. We investigated the seroepidemiology of the dengue virus for monitoring of Korean dengue virus immunity and establishing the prevention of dengue infection.
Methods
The study was based on 446 residual sera collected from 98 infants (2 months to 1 year old), 152 adolescents (13 to 19 years old), 90 adults (20 to 50 years old), and 106 elderly participants (more than 65 years old) for other studies. Antibody levels for dengue virus immunoglobulin G (IgG) in each age group were measured using an enzyme-linked immunosorbent assay (ELISA). For each dengue virus IgG positive or equivocal result, an IgG ELISA was performed for Japanese encephalitis virus.
Results
Of the 446 serum samples, only 1 (0.2%) adolescent had a positive result from the dengue IgG antibody test. In the dengue virus IgG antibody test, 14 (3.1%) samples showed equivocal results (10 adolescents and 4 elderly). In the 1 positive case of dengue virus IgG, the Japanese encephalitis IgG test was also positive. In the 14 equivocal cases of dengue virus IgG, there were 6 positive, 3 equivocal, and 5 negative of Japanese encephalitis IgG.
Figures and Tables
Fig. 1
The result of JEV IgG ELISA for 15 Dengue positive and equivocal serum.
Abbreviations: JEV, Japanese encephalitis virus; IgG, immunoglobulin G; ELISA, enzyme-linked immunosorbent assay.
Table 1
Demographic characteristics of the subjects (n=446)
Table 2
Seroprevalence results of Dengue IgG ELISA in infant, adolescent, adult and elderly groups
Notes
Funding This study was supported by the 2017 grant of Korean Society of Pediatric Infectious Diseases and the Ewha Womans University Department of Pediatrics Research Fund (2015EUPR0802).
Author Contributions
Conceptualization: Lee JH, Kim HW, Kim KH.
Data curation: Lee JH, Kim HW, Kim KH.
Formal analysis: Lee JH, Kim HW.
Funding acquisition: Lee JH, Kim HW.
Investigation: Lee JH, Kim HW.
Methodology: Lee JH, Kim HW.
Project administration: Lee JH, Kim HW.
Resources: Lee JH, Kim HW, Kim KH.
Software: Lee JH, Kim HW.
Supervision: Lee JH, Kim HW, Kim KH.
Validation: Lee JH, Kim HW.
Visualization: Lee JH, Kim HW, Kim KH.
Writing - original draft: Lee JH, Kim HW, Kim KH.
Writing - review & editing: Lee JH, Kim HW, Kim KH.
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