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Nguyen, Le, Zhao, Ma, Min, and Woo: Antioxidant Compounds Isolated from the Roots of Phlomis umbrosa Turcz.
Original Article

Natural Product Sciences 2018;24(2):119-124.

Published online: 20 January 2018

DOI: https://doi.org/10.20307/nps.2018.24.2.119

Antioxidant Compounds Isolated from the Roots of Phlomis umbrosa Turcz.

Duc Hung Nguyen1, 2, Duc Dat Le1, Bing Tian Zhao1, 3, Eun Sook Ma1, Byung Sun Min1, Mi Hee Woo1, ∗

1College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea

2Center for Drug Research and Technology Transfer, Phutho College of Medicine and Pharmacy, Viettri City, Phutho Province 290000, Vietnam

3School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China

∗Author for correspondence Mi Hee Woo, College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongsan 38430, Republic of Korea. Tel: +82-053-850-3620; E-mail: woomh@cu.ac.kr

Received 21 September 2017       Revised 22 January 2018       Accepted 23 January 2018

Copyright © 2018 The Korean Society of Pharmacognosy

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two triterpenoids, arjunolic acid (1), belleric acid (2), five phenylethanoids, martynoside (3), orobanchoside (4), 3,4-dihydroxyphenethylalcohol-6-O-caffeoyl-β-D-glucoside (5), leucosceptoside B (6), lunarii-folioside (7), four phenolic acids, ferulic acid (8), syringic acid (9), vanillic acid (10), 4-hydroxybenzoic acid (11), and one lignan, (+)-syringaresinol-β-D-glucoside (12), were isolated from the roots of P. umbrosa. All isolated compounds were explored for their antioxidant potential in the DPPH and ABTS assays. In DPPH assay, compound 5 showed high antioxidant capacity. Compounds 3, 4, 6, and 7 displayed considerable antioxidant activities. In addition, compounds 5–7 exhibited potential antioxidant capacities in the ABTS assay.

Keywords: Phlomis umbrosa, triterpenoids, phenylethanoids, phenolics, antioxidant

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Fig. 1.
The structures of isolated compounds (1 – 12) from the roots of P. umbrosa.
nps-24-119f1.tif
Table 1.
The antioxidant capacities of isolated compounds (1–12) in DPPH and ABTS assay
Compound IC50 of DPPH (µM) IC50 of ABTS (µM)
1 > 100 > 100
2 > 100 > 100
3 89.2 ± 2.5 > 100
4 91.4 ± 3.6 > 100
5 14.1 ± 1.4 56.3 ± 2.5
6 74.6 ± 2.4 87.3 ± 2.7
7 62.7 ± 1.9 70.1 ± 3.5
8 > 100 > 100
9 > 100 > 100
10 > 100 > 100
11 > 100 > 100
12 > 100 > 100
L-Ascorbic acid 2.4 ± 0.2 2.8 ± 0.1
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