The Quality of Life of Hemodialysis Patients Is Affected Not Only by Medical but also Psychosocial Factors: a Canonical Correlation Study

Kyungmin Kim; Gun Woo Kang; Jungmin Woo

doi:10.3346/jkms.2018.33.e111

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Kim, Kang, and Woo: The Quality of Life of Hemodialysis Patients Is Affected Not Only by Medical but also Psychosocial Factors: a Canonical Correlation Study

Original Article

Nephrology

Journal of Korean Medical Science 2018; 33(14): e111.

Published online: 13 March 2018

DOI: https://doi.org/10.3346/jkms.2018.33.e111

The Quality of Life of Hemodialysis Patients Is Affected Not Only by Medical but also Psychosocial Factors: a Canonical Correlation Study

Kyungmin Kim¹

, Gun Woo Kang²

, Jungmin Woo¹

¹Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Korea.

²Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.

Address for Correspondence: Jungmin Woo, MD. Department of Psychiatry, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Republic of Korea. woojm3@hanmail.net

Received 22 November 2017 Accepted 31 January 2018

The Korean Academy of Medical Sciences

(open-access, https://creativecommons.org/licenses/by-nc/4.0/):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

The quality of life (QoL) of patients with end-stage renal disease (ESRD) is very poor, plausibly due to both psychosocial and medical factors. This study aimed to determine the relationship among psychosocial factors, medical factors, and QoL in patients with ESRD undergoing hemodialysis (HD).

Methods

In total, 55 male and 47 female patients were evaluated (mean age, 57.1 ± 12.0 years). The QoL was evaluated using the Korean version of World Health Organization Quality of Life Scale-Abbreviated Version. The psychosocial factors were evaluated using the Hospital Anxiety and Depression Scale, Multidimensional Scale of Perceived Social Support, Montreal Cognitive Assessment, Pittsburgh Sleep Quality Index, and Zarit Burden Interview. The medical factors were assessed using laboratory examinations. Correlation and canonical correlation analyses were performed to investigate the association patterns.

Results

The QoL was significantly correlated with the psychosocial factors, and to a lesser extent with the medical factors. The medical and psychosocial factors were also correlated. The canonical correlation analysis indicated a correlation between QoL and psychosocial factors (1st canonical correlation = 0.696, P < 0.001; 2nd canonical correlation = 0.421, P = 0.191), but not medical factors (1st canonical correlation = 0.478, P = 0.475; 2nd canonical correlation = 0.419, P = 0.751). The medical and psychosocial factors were also correlated (1st canonical correlation = 0.689, P < 0.001; 2nd canonical correlation = 0.603, P = 0.009).

Conclusion

Psychosocial factors influence QoL in patients with ESRD, and should thus be carefully considered when caring for these patients in clinical practice.

Graphical Abstract

Keywords: Psychosocial Factor, Medical Factor, Quality of Life, End-stage Renal Disease, Canonical Correlation Analysis

INTRODUCTION

End-stage renal disease (ESRD) is a serious public health problem associated with poor quality of life (QoL).1 2 In Korea, the number of patients with ESRD undergoing dialysis has been rapidly growing in recent years, especially in elderly patients. The total number of patients with renal replacement therapy (RRT) in Korea was 75,042 in 2013. The prevalence of RRT was 1,446.4 patients per million population.3 The concept of health-related QoL (HRQoL) of the World Health Organization (WHO) is defined as the subjective assessment of the impact of disease and its treatment across the physical, psychological, and social domains of functioning and well-being.4 Low HRQoL scores in dialysis patients are strong independent predictors of hospitalization and mortality.5

The treatment of ESRD is challenging and lengthy, and requires to improve QoL in addition to survival.6 However, many patients with ESRD do not report improvement in their QoL after they initiate the hemodialysis (HD).7 8 9 Thus, we assume that factors other than medical factors are implicated in the QoL of patients with ESRD. Indeed, emotional and social factors may also influence QoL. However, the psychosocial factors are often overlooked in the medical field. Thus, we investigated the impact of both psychosocial and medical factors on QoL in patients with ESRD undergoing HD. There are few studies that have evaluated the medical and psychosocial factors that are associated with HRQoL in HD patients. However, most studies have used Short-Form 36 (SF-36) or EuroQoL-5 Dimensions (Eq-5D) to measure HRQoL. Moreover, only few studies evaluated the association between HRQoL and psychosocial factors and used multivariate analysis for a comprehensive understanding.

The present study used the WHO Quality of Life Scale-Abbreviated Version (WHOQOL-BREF) to measure QoL in patients with ESRD. Furthermore, we used the canonical correlation analysis to analyze comprehensively the psychosocial and medical factors; indeed, QoL can be explained clearly by multivariate rather than univariate analysis.

METHODS

Patients and study design

Out of 155 patients with ESRD, undergoing HD at the Daegu Catholic University Medical Center between September and October 2013, we selected those who could complete the questionnaires individually. Patients were excluded if they were receiving HD because of acute kidney injury, hospitalized with a psychotic spectrum disorder, or under 20 or over 80 years of age. Finally, QoL was assessed in 102 patients using the WHOQOL-BREF along with measurements of medical and psychosocial factors.

Measurement of QoL

The WHOQOL-100 was developed to perform QoL assessments that would be applicable cross-culturally. Although WHOQOL-100 allows detailed assessment of each individual facet relating to QoL, it may be too lengthy for practical use. Thus, the WHOQOL-BREF Field Trial Version, a shorter version consisting of 26 questions, was developed instead. The WHOQOL-BREF produces a QoL profile and enables the determination of four domain scores: physical health, psychosocial, social, and environmental. There are also two items that are examined separately, namely the individual's overall perception of QoL and health. The four domain scores denote an individual's perception of QoL in each particular domain. They are scaled in a positive direction, with the higher scores denoting higher QoL. Each domain has 4–20 score variations. In this study, the Korean version of WHOQOL-BREF has been used.10 11 12

Medical measurements

Biomarkers for all patients included blood test analyses, body mass index (BMI), causes of ESRD, HD duration, clearance × time/volume (Kt/V), normalized protein catabolic rate (nPCR), and Charlson Comorbidity Index (CCI) score. Blood test analyses included hemoglobin, total cholesterol, calcium, phosphorus, 25-hydroxyvitamin D also known as 25(OH)D, ferritin, and intact parathyroid hormone (iPTH). The Kt/V indicates a function of the dialyzer urea clearance, treatment time, and urea distribution volume, and is commonly used as a marker for dialysis adequacy. The CCI score predicts 10-year mortality for a patient who may have some comorbid conditions. The nPCR is a formula to assess dietary protein intake in dialysis patients, and is reported in grams of urea nitrogen per kilogram per day.

Psychosocial measurements

The psychosocial factors were evaluated using the Hospital Anxiety and Depression Scale (HADS), Multidimensional Scale of Perceived Social Support (MSPSS), Montreal Cognitive Assessment (MOCA), and Pittsburgh Sleep Quality Index (PSQI). Furthermore, the main caregivers were interviewed using the Zarit Burden Interview (ZBI) to evaluate their burden as another psychosocial factor.

The HADS is a 14-item self-report screening scale that was developed to determine the anxiety and depression states in the setting of a non-psychiatric outpatient clinic.13 The HADS consists of a 7-item anxiety subscale (HADS-A) and a 7-item depression subscale (HADS-D). Each item is scored on a 4-point Likert scale, resulting in a maximum subscale score of 21 for anxiety and depression, respectively. The sum of each subscale indicates the level of anxiety and depression (0–7 = normal; 8–10 = borderline abnormal; 11–21 = abnormal).

The MSPSS is a 12-item scale scored using a 7-point scale (1 = strongly disagree to 7 = strongly agree), and measures three subscales corresponding to three sources of support: family, friends, and others.14 This scale is short and easy to understand, and can be performed by individuals who cannot tolerate long questionnaires or who have a limited literacy level. The subscale “others” was deﬁned as the medical team.

The MOCA was developed as a brief screening instrument to detect mild cognitive impairment (MCI). It requires approximately 10 minutes and has a maximum score of 30 points. The MOCA assesses multiple cognitive domains including attention, concentration, executive functions, memory, language, visuospatial skills, abstraction, calculation, and orientation.15 In general, a total score of 22 or lower indicates cognitive impairments. We used the Korean version of the MOCA in the present study.

The PSQI is an instrument used to measure the quality and patterns of sleep. It differentiates ‘poor’ from ‘good’ sleep by measuring seven domains: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleep medications, and daytime dysfunction over the last month. Each of the seven domains is subjectively rated by the patients. The PSQI is scored based on a 4-point Likert scale, where 0 reflects the positive extreme and 3 reflects the negative extreme. A global score of 5 or greater indicates poor sleep.16

The ZBI is a 22-item instrument for measuring the caregiver's perceived burden of providing family care. The 22 items are assessed on a 5-point Likert scale, ranging from 0 (never) to 4 (nearly always). The total score corresponds to the sum of the item scores and ranges from 0 to 88, with higher scores indicating greater burden. The questions focus on the caregiver's health, psychological well-being, ﬁnances, social life, and relationship between the caregiver and the patient.17

Ethics statement

The Institutional Review Board of Daegu Catholic University Medical Center approved this study (IRB No. CR-13-076) and all participants provided written informed consent.

Statistical analysis

Statistical analysis was performed using SAS 9.3 Win ver. 6.1 (SAS Institute Inc., Cary, NC, USA). The results were presented as mean ± standard deviation. The associations between QoL and medical and/or psychosocial factors were assessed using correlation and canonical correlation analyses.

Canonical correlation analysis is used to investigate the interrelationships between sets of multiple dependent and independent variables. It is a generalization of multiple regression analysis with more than one set of dependent variables. Therefore, this statistical method enables studying the complex interactions of data from two sets of variables.18 In this study, the analysis was done between three sets of variables, each of which had virtual variants for QoL, medical factors, and psychosocial factors. We developed canonical functions for each analysis in such a way that the cumulative proportion exceeded 70%.

RESULTS

Characteristics of HD patients

A total of 102 patients (55 men, 47 women; mean age, 57.1 ± 12.0 years) receiving HD were recruited for the study. The demographic, medical, and psychosocial data of the 102 patients are listed in Table 1. The mean duration of HD was 36.0 ± 35.9 months. Diabetes mellitus (52.0%) was the most common cause of ESRD, followed by hypertension (21.6%).

Table 1

Demographic, clinical, and psychosocial parameters of the patients

Variables			Value (n = 102)
Demographics
	Age, yr		57.1 ± 12.0
	Male:female		55 (53.9):47 (46.1)
	Cause of ESRD
		Diabetes mellitus	53 (52.0)
		Hypertension	22 (21.6)
		Chronic glomerulonephritis	12 (11.7)
		Others	15 (14.7)
Clinical laboratory parameters
	BMI, kg/m²		22.1 ± 3.0
	Total cholesterol, mg/dL		137.24 ± 33.01
	nPCR, g/kg/day		0.82 ± 0.18
	Hemoglobin, g/dL		10.09 ± 1.08
	Calcium, mg/dL		8.99 ± 0.76
	Phosphorus, mg/dL		5.45 ± 1.91
	Ferritin, ng/mL		242.60 ± 223.64
	25(OH)D, ng/mL		16.42 ± 8.94
	iPTH		337.05 ± 263.71
	CCI score		3.92 ± 1.40
	Duration of HD, mon		36.03 ± 35.93
	Kt/V		1.44 ± 0.57
Psychosocial parameters
	WHOQOL-BREF
		Physical health	10.05 ± 2.84
		Psychological	10.17 ± 2.69
		Social relationship	10.65 ± 2.91
		Environment	10.44 ± 2.28
	HADS-A		6.04 ± 4.17
	HADS-D		9.49 ± 4.03
	MOCA		19.26 ± 7.78
	MSPSS		36.4 ± 9.9
	PSQI		8.31 ± 4.65
	ZBI		18.62 ± 22.89

Values are presented as mean ± standard deviation or number (%).

ESRD = end-stage renal disease, BMI = body mass index, nPCR = normalized protein catabolic rate, 25(OH)D = 25-hydroxyvitamin D, iPTH = intact parathyroid hormone, CCI = Charlson Comorbidity Index, HD = hemodialysis, HADS = Hospital Anxiety and Depression Scale, Kt/V = clearance × time/volume, WHOQOL-BREF = world health organization quality of life scale-abbreviated version, HADS-A = Hospital Anxiety and Depression Scale consists of a 7-item anxiety subscale, HADS-D = Hospital Anxiety and Depression Scale consists of a 7-item depression subscale, MOCA = Montreal Cognitive Assessment, MSPSS = Multidimensional Scale of Perceived Social Support, PSQI = Pittsburgh Sleep Quality Index, ZBI = Zarit Burden Interview.

Correlation between the WHOQOL score and the medical factors

First, we investigated the relationship between multiple variants by correlation analysis. Table 2 summarizes the correlation coefficients and the P values, and indicates multiple correlations. The physical health domain was positively correlated with nPCR (r = 0.235, P = 0.022) and phosphorus (r = 0.202, P = 0.045). In the psychological domain, we observed a negative correlation with the HD duration (r = −0.222, P = 0.027), indicating that a lower psychological QoL was associated with longer HD duration. In the social relationship domain, phosphorus (r = 0.236, P = 0.019) and iPTH (r = 0.224, P = 0.026) were positively associated with QoL. In the environment domain, nPCR (r = 0.239, P = 0.02) was positively correlated with QoL.

Table 2

Results of the correlation analysis

Variables	DOM1	DOM2	DOM3	DOM4	HADS-A	HADS-D	MOCA	MSPSS	ZBI	PSQI	Age
BMI	0.185	0.181	0.027	0.12	0.151	−0.119	−0.006	0.113	−0.1	−0.117	0.091
BMI	(0.067)	(0.074)	(0.794)	(0.237)	(0.134)	(0.237)	(0.95)	(0.264)	(0.327)	(0.247)	(0.368)
HD_DUR	−0.198	−0.222^a	−0.092	−0.16	−0.029	0.207^a	−0.209^a	−0.039	−0.137	−0.017	0.172
HD_DUR	(0.05)	(0.027)	(0.364)	(0.114)	(0.777)	(0.039)	(0.037)	(0.701)	(0.176)	(0.87)	(0.086)
CCI	−0.088	−0.033	−0.101	0.066	−0.234^a	0.062	−0.061	0.074	0.036	0.083	0.254^a
CCI	(0.388)	(0.745)	(0.319)	(0.515)	(0.019)	(0.541)	(0.545)	(0.462)	(0.721)	(0.409)	(0.011)
Kt/V	−0.036	−0.026	0.191	0.117	−0.122	−0.009	−0.185	−0.001	−0.103	0.138	0.094
Kt/V	(0.731)	(0.803)	(0.064)	(0.259)	(0.235)	(0.934)	(0.071)	(0.994)	(0.321)	(0.179)	(0.365)
nPCR	0.235^a	0.167	0.162	0.239^a	0.031	−0.221^a	0.12	−0.064	−0.134	0.038	0.041
nPCR	(0.022)	(0.105)	(0.116)	(0.02)	(0.764)	(0.03)	(0.244)	(0.535)	(0.195)	(0.712)	(0.694)
Hb	0.064	0.152	0.121	0.079	0.09	−0.067	0.051	0.051	0.154	0.135	−0.122
Hb	(0.527)	(0.134)	(0.233)	(0.438)	(0.371)	(0.508)	(0.617)	(0.616)	(0.128)	(0.182)	(0.225)
Alb	0.122	0.011	0.161	0.058	0.111	−0.038	0.012	0.03	−0.212^a	0.064	−0.229^a
Alb	(0.228)	(0.915)	(0.111)	(0.567)	(0.27)	(0.705)	(0.908)	(0.771)	(0.035)	(0.526)	(0.022)
Tchol	0.073	−0.002	0.052	−0.012	−0.201^a	−0.078	−0.181	−0.023	0.065	−0.07	0.002
Tchol	(0.47)	(0.986)	(0.609)	(0.908)	(0.044)	(0.44)	(0.072)	(0.82)	(0.52)	(0.49)	(0.983)
Ca	−0.104	−0.012	−0.051	−0.054	0.127	0.092	−0.029	0.023	−0.069	0.202^a	−0.07
Ca	(0.305)	(0.907)	(0.616)	(0.593)	(0.208)	(0.362)	(0.775)	(0.82)	(0.495)	(0.044)	(0.486)
P	0.202^a	0.139	0.236^a	0.096	0.04	−0.062	0.261^b	0.07	−0.107	0.207^a	−0.255^a
P	(0.045)	(0.17)	(0.019)	(0.345)	(0.693)	(0.539)	(0.009)	(0.487)	(0.293)	(0.038)	(0.01)
Ferritin	0.03	−0.065	−0.075	−0.026	−0.007	0.046	0.055	−0.129	−0.047	−0.025	−0.195
Ferritin	(0.767)	(0.521)	(0.461)	(0.795)	(0.943)	(0.653)	(0.587)	(0.199)	(0.641)	(0.803)	(0.052)
iPTH	0.169	0.103	0.224^a	0.052	0.005	−0.081	−0.073	0.154	−0.09	0.132	−0.065
iPTH	(0.095)	(0.312)	(0.026)	(0.609)	(0.959)	(0.423)	(0.472)	(0.126)	(0.373)	(0.19)	(0.522)
25(OH)D	0.059	0.019	0.023	0.034	0.204^a	0.006	−0.011	−0.139	−0.135	0.034	0.046
25(OH)D	(0.564)	(0.854)	(0.822)	(0.737)	(0.042)	(0.955)	(0.912)	(0.168)	(0.183)	(0.74)	(0.647)
DOM1					−0.263^b	−0.464^b	0.25^a	0.287^b	−0.15	−0.259^b	−0.161
DOM1					(0.008)	(0)	(0.012)	(0.004)	(0.138)	(0.009)	(0.108)
DOM2					−0.381^b	−0.556^b	0.158	0.413^b	−0.048	−0.095	−0.065
DOM2					(0)	(0)	(0.114)	(0)	(0.636)	(0.342)	(0.52)
DOM3					−0.292^b	−0.381^b	0.057	0.397^b	−0.107	−0.029	−0.09
DOM3					(0.003)	(0)	(0.569)	(0)	(0.291)	(0.771)	(0.368)
DOM4					−0.215^a	−0.39^b	0.197^a	0.312^b	−0.104	−0.212^a	−0.032
DOM4					(0.031)	(0)	(0.048)	(0.002)	(0.302)	(0.034)	(0.754)

Values are presented by correlation coefficient (P value).

25(OH)D = 25-hydroxyvitamin D, Alb = albumin, Ca = calcium, BMI = body mass index, CCI = Charlson comorbidity index, DOM1 = physical health domain of WHOQOL-BREF, DOM2 = psychosocial domain of WHOQOL-BREF, DOM3 = social relationships domain of WHOQOL-BREF, DOM4 = environmental domain of WHOQOL-BREF, Hb = hemoglobin, HADS = Hospital Anxiety and Depression Scale, HADS-A = Hospital Anxiety and Depression Scale consists of a 7-item anxiety subscale, HADS-D = Hospital Anxiety and Depression Scale consists of a 7-item depression subscale, HD_DUR = duration of dialysis, iPTH = intact parathyroid hormone, Kt/V = clearance × time/volume, MOCA = Montreal Cognitive Assessment, MSPSS = Multidimensional Scale of Perceived Social Support, nPCR = normalized protein catabolic rate, P = phosphorus, PSQI = Pittsburgh Sleep Quality Index, WHOQOL-BREF = World Health Organization Quality of Life Scale-Abbreviated Version, ZBI = Zarit Burden Interview, Tchol = total cholesterol.

^aP < 0.05; ^bP < 0.01.

Subsequently, we performed canonical correlation analysis to investigate concretely the structure of the correlations in a manner similar to multivariate analysis. The results indicated no significant correlation between QoL and medical factors (1st canonical function: r = 0.478, P = 0.475; 2nd canonical function: r = 0.419, P = 0.751; Table 3). Table 4 shows canonical coefficients, correlation loadings and cross correlation loadings for each of functions between QoL and medical factors.

Table 3

Results of the canonical correlation analysis

Variable groups	Canonical function	Canonical correlation	Eigen value	Wilk's λ	Proportion	P value
WHOQOL & medical factors	First	0.478	0.294	0.542	0.438	0.475
WHOQOL & medical factors	Second	0.419	0.213	0.702	0.316	0.751
WHOQOL & psychosocial factors	First	0.696	0.938	0.403	0.778	0.000
WHOQOL & psychosocial factors	Second	0.421	0.215	0.781	0.178	0.191
Medical factors & psychosocial factors	First	0.689	0.901	0.152	0.435	0.000
Medical factors & psychosocial factors	Second	0.603	0.572	0.289	0.294	0.009

WHOQOL = World Health Organization Quality of Life Scale.

Table 4

Canonical weights and loadings for the functions (WHOQOL score & medical factors)

Variable groups	Variables	The 1st canonical function			The 2nd canonical function
Variable groups	Variables	Coefficients	Correlation	Cross correlation	Coefficients	Correlation	Cross correlation
WHOQOL	DOM1	1.098	0.892	0.427	−0.017	0.387	0.162
	DOM2	−0.228	0.462	0.221	0.990	0.706	0.296
	DOM3	0.386	0.632	0.302	−0.865	−0.145	−0.061
	DOM4	−0.458	0.259	0.124	0.401	0.455	0.191
Medical factors	BMI	0.104	0.241	0.115	0.317	0.451	0.189
	HD_DUR	−0.462	−0.281	−0.134	−0.450	−0.459	−0.193
	CCI	−0.352	−0.374	−0.179	0.154	0.258	0.108
	Kt/V	−0.221	−0.027	−0.013	−0.412	−0.342	−0.144
	nPCR	0.050	0.363	0.173	0.656	0.279	0.117
	Hb	−0.149	0.105	0.050	0.394	0.198	0.083
	Alb	0.281	0.360	0.172	−0.605	−0.355	−0.149
	Tchol	0.262	0.257	0.123	−0.165	−0.175	−0.073
	Ca	−0.391	−0.223	−0.107	0.419	−0.018	−0.008
	P	0.348	0.485	0.232	−0.269	0.001	0.001
	Ferritin	0.128	0.111	0.053	0.231	−0.051	−0.021
	iPTH	0.563	0.460	0.220	0.068	−0.155	−0.065
	25(OH)D	0.064	0.099	0.047	−0.087	0.052	0.022

Correlation between the WHOQOL score and the psychosocial factors

Table 2 summarizes the significant correlations between the different variables. All the WHOQOL domains were negatively correlated with both HADS-A and HADS-D. The MOCA score was positively correlated with the physical health and environment domains, suggesting that these two domains may be related to the patients' cognition. There were also significantly positive correlations between the MSPSS score and all QoL domains, indicating that support from others can highly influence the patients' QoL. In addition, the physical health and environment domains were negatively correlated with the PSQI score, suggesting that patients who experience poor sleep could have lower physical health and environment quality.

The canonical correlation analysis indicated significant positive correlations between QoL and the psychosocial factors (1st canonical function: correlation = 0.696, P < 0.001; 2nd canonical function: correlation = 0.421, P = 0.191; Table 3). The proportion explaining the variance attributed to a given canonical correlation was 0.778 in the 1st canonical function.

In the canonical cross correlation loading of the 1st canonical function, we found that three variants including HADS-A (−0.394), HADS-D (−0.585), and MSPSS (0.455) contributed to the correlation between QoL and the psychosocial factors (Table 5). This is in line with a previous suggestion by Tabachnick and Fidell19 proposing that the structure coefficient is interpreted as meaningful when its value exceeds 0.3. Thus, higher anxiety and depression scores may be associated with lower QoL, while better support from others results in a higher QoL.

Table 5

Canonical weights and loadings for the functions (WHOQOL score & psychosocial factors)

Variable groups	Variables	The 1st canonical function			The 2nd canonical function
Variable groups	Variables	Coefficients	Correlation	Cross correlation	Coefficients	Correlation	Cross correlation
WHOQOL	DOM1	0.082	0.742	0.516	−1.031	−0.552	−0.232
	DOM2	0.645	0.939	0.654	0.534	0.090	0.038
	DOM3	0.255	0.754	0.524	0.715	0.296	0.125
	DOM4	0.210	0.676	0.470	−0.407	−0.421	−0.177
Psychosocial factors	HADS-A	−0.108	−0.566	−0.394	−0.347	−0.120	−0.050
	HADS-D	−0.736	−0.841	−0.585	−0.020	0.178	0.075
	MOCA	0.035	0.266	0.185	−0.704	−0.521	−0.219
	MSPSS	0.482	0.654	0.455	0.198	0.199	0.084
	ZBI	−0.117	−0.132	−0.092	0.211	0.225	0.095
	PSQI	0.092	−0.179	−0.124	0.811	0.661	0.278
	Age	0.032	−0.127	−0.088	−0.139	0.196	0.083

DOM1 = physical health domain of WHOQOL-BREF, DOM2 = psychosocial domain of WHOQOL-BREF, DOM3 = social relationships domain of WHOQOL-BREF, DOM4 = environmental domain of WHOQOL-BREF, HADS_A = Hospital Anxiety and Depression Scale consists of a 7-item anxiety subscale, HADS-D = Hospital Anxiety and Depression Scale consists of a 7-item depression subscale, MOCA = Montreal Cognitive Assessment, MSPSS = Multidimensional Scale of Perceived Social Support, PSQI = Pittsburgh Sleep Quality Index, WHOQOL-BREF = World Health Organization Quality of Life Scale-Abbreviated Version, ZBI = Zarit Burden Interview.

Association between the medical and psychosocial factors

The correlation analysis indicated positive and negative relationships between the medical and psychosocial factors. The HD duration was positively correlated with the HADS-D score and negatively correlated with the MOCA score, which indicates that explain the higher depression score and lower cognitive function may be associated with longer HD durations. Phosphorus was correlated with MOCA, PSQI, and age, while CCI was positively correlated with age (Table 2).

The canonical correlation analysis indicated a positive correlation between the medical and psychological factors (1st canonical function: correlation = 0.689, P < 0.001; 2nd canonical function: correlation = 0.603, P = 0.009; Table 3). The proportion of the 1st and 2nd canonical functions was 0.435 and 0.294, respectively.

In the canonical cross correlation loading of the 1st canonical function, we found that only phosphorus (0.360) was implicated in the correlations observed with the medical variants, while both the MOCA score (0.386) and age (−0.560) were implicated in the correlations with the psychosocial variants (Table 6).

Table 6

Canonical weights and loadings for the functions (medical factors & psychosocial factors)

Variable groups	Variables	The 1st canonical function			The 2nd canonical function
Variable groups	Variables	Coefficients	Correlation	Cross correlation	Coefficients	Correlation	Cross correlation
Medical factors	BMI	−0.132	0.004	0.002	−0.487	−0.506	−0.305
	HD_DUR	−0.691	−0.410	−0.283	−0.071	0.132	0.080
	CCI	−0.297	−0.373	−0.257	0.433	0.379	0.229
	Kt/V	−0.310	−0.173	−0.119	0.229	0.222	0.134
	nPCR	−0.164	0.093	0.064	−0.732	−0.410	−0.247
	Hb	0.251	0.358	0.246	0.134	0.060	0.036
	Alb	0.116	0.339	0.234	−0.032	−0.146	−0.088
	Tchol	−0.250	−0.171	−0.118	0.180	0.277	0.167
	Ca	0.222	0.177	0.122	0.011	0.041	0.025
	P	0.464	0.522	0.360	0.449	0.059	0.035
	Ferritin	0.285	0.159	0.109	−0.105	0.107	0.065
	iPTH	0.409	0.184	0.127	0.137	0.093	0.056
	25(OH)D	−0.246	0.026	0.018	−0.367	−0.427	−0.258
Psychosocial factors	HADS-A	0.427	0.278	0.191	−0.878	−0.530	−0.320
	HADS-D	−0.345	−0.207	−0.143	0.566	0.267	0.161
	MOCA	0.162	0.560	0.386	−0.287	−0.079	−0.048
	MSPSS	0.180	0.169	0.116	0.199	0.301	0.182
	ZBI	0.150	0.088	0.061	0.346	0.265	0.160
	PSQI	0.303	0.299	0.206	0.380	0.346	0.208
	age	−0.718	−0.815	−0.561	−0.422	−0.184	−0.111

25(OH)D = 25-hydroxyvitamin D, Alb = albumin, Ca = calcium, BMI = body mass index, CCI = Charlson comorbidity index, Hb = hemoglobin, HADS-A = Hospital Anxiety and Depression Scale consists of a 7-item anxiety subscale, HADS-D = Hospital Anxiety and Depression Scale consists of a 7-item depression subscale, HD_DUR = duration of dialysis, iPTH = intact parathyroid hormone, Kt/V = clearance × time/volume, MOCA = Montreal Cognitive Assessment, MSPSS = Multidimensional Scale of Perceived Social Support, nPCR = normalized protein catabolic rate, P = phosphorus, PSQI = Pittsburgh Sleep Quality Index, ZBI = Zarit Burden Interview, Tchol = total cholesterol.

DISCUSSION

As evidenced by both the correlation and canonical correlation analyses, there were significant and positive correlations between QoL and the psychosocial factors. On the other hand, although there were some correlations between QoL and the medical factors, these were not consistent. Indeed, we could not validate those correlations using the canonical correlation analysis. The results also indicated some positive correlations between the medical and psychosocial factors.

Although several studies have reported correlations between QoL and medical and psychosocial factors in patients with chronic illnesses, these are still debated to date. Cruz et al.20 suggested that more sociodemographic factors were associated with decreased QoL than medical factors. However, our present results indicated that the medical factors were also strongly implicated.

Spiegel et al.21 suggested that the HRQoL score in patients with ESRD is most affected by medical factors and nutritional biomarkers. However, they demonstrated poor correlations with Kt/V, mineral metabolism indices, and inflammatory markers. Soni et al.22 suggested that anemia and depression are also determinants of HRQoL in patients with chronic kidney disease. In contrast, Mazairac et al.23 reported that widely accepted clinical performance targets that are recommended by the Kidney Disease Outcomes Quality Initiative, including Kt/V, hemoglobin, vascular access, phosphorus, parathyroid hormone, and blood pressure, were not related to the HRQoL score in HD patients. Furthermore, Saad et al.24 demonstrated similar results indicating no significant correlation between medical factors and QoL in patients with ESRD.

Our present findings are in line with previous findings and indicate that the medical factors can influence the psychosocial factors directly, and the QoL indirectly. Thus, evaluating only clinical parameters without taking the psychosocial aspects into account may attenuate the effective prediction of the patients' QoL throughout the course of the disease.

Our results indicated significant correlations between the psychosocial factors and QoL. In particular, correlations with depression, anxiety, and support from others were the most notable. Previous studies showed that anxiety and depression are important aspects in QoL in people with chronic illnesses. Dogan et al.25 reported a correlation among high depression score, low SF-36 score, high anxiety score, and QoL in patients with Huntington's disease. Other studies have also confirmed the relationship between QoL and the social support in patients with Huntington's disease.26 Untas et al.27 suggested that poorer social supports are associated with higher mortality risk, lower adherence to medical care, and poorer physical QoL in HD patients. However, there are also few studies that demonstrate a strong correlation between QoL and other psychosocial factors such as cognition, sleep disturbance in patients with chronic illnesses. In the present study, the low range of depression/anxiety and the high range of support from others were more relevant for QoL than other factors. However, these discrepancies may be the result of differences in ethnicities and customs.

Our results indicated correlations between the medical and psychosocial factors, which were validated using the canonical correlation analysis, particularly in terms of two factors, which is in line with a previous study.28 In particular, the younger age and better cognitive function were proven to influence the medical factors of patients with ESRD. It is worth noting that cognition was important for improving the patients' clinical condition, but was not directly related to their QoL. In addition, we also investigated whether there were correlations between the patients' age and QoL. Our results indicated no correlation in both the correlation and canonical correlation analyses. In contrast, age was related to several medical factors. In a recent study, Laudański et al.29 suggested that younger patients required more ESRD-oriented support to relieve their health-related complaints than older patients. These results indicate that younger patients may also have lower QoL. In contrast, Kutner et al.30 suggested that older patients on dialysis reported more functional disabilities, decreased ability to do the things they would like to do, and lower levels of perceived mastery over their lives; this correlation was further debated in other studies.31 32

Our study had several limitations. There may have been a selection bias when choosing the medical and psychosocial factors, which did not represent all the factors we aimed to investigate. In addition, the sample size was relatively small, and the study was based on results from a single center. Thus, future studies using a larger sample size and multiple centers are still warranted to validate our findings. Despite these limitations, our present study had the advantage of using canonical correlation analysis to validate the correlations between the groups of factors, and using the WHOQOL-BREF score to analyze many aspects of QoL. Furthermore, vigorous and broad investigations to evaluate the patients' characteristics were performed.

In conclusion, this study suggested that there is a strong correlation between psychosocial factors and QoL in patients with ESRD undergoing HD. The psychosocial and medical factors were also correlated. However, the medical factors were not correlated with QoL in our present study; thus, further research on this point is still needed. Our findings suggest that medical workers should recognize and treat the psychosocial and medical complications equally. Moreover, active consultation liaison is needed between the nephrologists and psychiatrists to improve QoL in patients with ESRD.

Notes

Disclosure: The authors have no potential conflicts of interest to disclose.

Author Contributions: Conceptualization: Kang GW, Woo J. Data curation: Kang GW, Woo J. Formal analysis: Woo J, Kim K. Investigation: Kang GW, Woo J. Writing - original draft: Kim K, Woo J. Writing - review & editing: Kim K, Kang GW, Woo J.

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TOOLS

ORCID iDs

Kyungmin Kim
https://orcid.org/0000-0001-9304-0404

Gun Woo Kang
https://orcid.org/0000-0001-8003-2552

Jungmin Woo
https://orcid.org/0000-0001-7180-9972

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