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Kim, Kim, and Choi: Adenoidectomy May Not Be Effective to Reduce the Number of Hospital Visits for Sinusitis
Original Article
Otorhinolaryngology

Journal of Korean Medical Science 2018; 33(10): e78.

Published online: 30 January 2018

DOI: https://doi.org/10.3346/jkms.2018.33.e78

Adenoidectomy May Not Be Effective to Reduce the Number of Hospital Visits for Sinusitis

Min-Su Kim1, So Young Kim1, Hyo Geun Choi2

1Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

2Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Address for Correspondence: Hyo Geun Choi, MD. Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22 Gwanpyeong-ro 170-beon-gil, Dongan-gu, Anyang 14068, Republic of Korea. pupen@naver.com

Received 30 September 2017       Accepted 27 December 2017

© 2018 The Korean Academy of Medical Sciences.

The Korean Academy of Medical Sciences

(open-access, https://creativecommons.org/licenses/by-nc/4.0/):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

The objective of this study was to compare post-operative (post-op) visits for sinusitis between adenoidectomy and non-adenoidectomy participants (control).

Methods

Using the national cohort study from the Korean Health Insurance Review and Assessment Service, we used 1:4 matching to select 2,593 adenoidectomy participants and 10,372 control participants. Post-op visits for sinusitis were measured from post-op 1 year through post-op 9 years. Equivalence testing was used. Margin of equivalence of difference was set as −0.5 to 0.5 in this study.

Results

There were trivial differences between the two groups from post-op 1 to 2 years. However, there was no difference between the two groups from post-op 3 through 9 years. Visits for sinusitis gradually decreased in both groups. In the rare and frequent pre-operative sinusitis group, there were minor differences in both groups from post-op 1 to 2 years. In contrast, there were no differences between the two groups in rare and frequent pre-operative sinusitis groups from post-op 3 through 9 years. In the 0–4 years old group, there were minor differences between both groups from post-op 1 to 2 years. However, no differences in the number of visits for sinusitis were found between the two groups during follow up periods from post-op 3 through 9 years. Additionally, there were no differences between the two groups during the entire follow up period.

Conclusion

Adenoidectomy does not reduce post-op visits for sinusitis. Sinusitis decreased over time whether adenoidectomy was performed or not.

Graphical Abstract

jkms-33-e78-abf001.jpg

Keywords: Adenoidectomy, Sinusitis, Case-Control Studies, Cohort Studies

INTRODUCTION

Adenoidectomy with/without tonsillectomy is a commonly performed pediatric otorhinolaryngology surgery. In 2006, 132,000 adenoidectomies without tonsillectomy were performed in children younger than 15 years of age in the United States.1 Our previous study reported that the rate for adenoidectomy with/without tonsillectomy was 0.8 per 1,000 in Korea.2
The adenoids are a mass of lymphoid tissues located in the superoposterior area of the nasopharynx and affect breathing in the upper airway. It is known that, in general, the adenoids are tiny in size at birth and consistently grow during several years after birth due to the hyperactivity of the immune system.3 The adenoids are known to cause either mechanical obstruction or stasis of secretions or may be a nidus causing repeated episodes of upper respiratory infection.4 Additionally, the adenoid can serve as a reservoir of pathogenic bacteria and recurrent or persistent adenoiditis is associated with common diseases of neighboring structures including sinusitis.5 In many children, adenoid hypertrophy and sinusitis are known to coexist. The association between the two conditions is variable, with some authors finding that an association exists678 and others showing that there is no such association.910
Indications for adenoidectomy are controversial. Widest agreement surrounds their removal for obstructive sleep apnea, usually combined with tonsillectomy.11 There is also support for adenoidectomy in recurrent otitis media in children previously treated with tympanostomy tubes.12 However, at present the effectiveness of adenoidectomy in children with recurrent or chronic nasal symptoms remains uncertain and practice is experience-based rather than evidence-based. Some surgeons prefer to perform adenoidectomy in these children,81314 whereas others do not.151617
The purpose of this study is to compare post-operative (post-op) visits for sinusitis between the adenoidectomy and non-adenoidectomy participants (control) using the national cohort study. In this study, we matched the adenoidectomy and control group as 1:4 for age, sex, income group, and the number of pre-operative sinusitis histories. We followed the participants at least 1 year, at maximum 9 years.

METHODS

Study population and data collection

This national cohort study relied on data from the Korean Health Insurance Review and Assessment Service-National Patient Sample (HIRA-NPS). The Korean National Health Insurance Service (NHIS) selected samples directly from the entire population database to prevent non-sampling errors. Approximately 2% of the samples (one million) were selected from the entire Korean population (50 million). This selected data could be classified into 1,476 levels (age [18 categories], sex [2 categories], and income level [41 categories]) using randomized stratified systematic sampling methods by proportional allocation to represent the entire population. After data selection, the appropriateness of the sample was verified by a statistician who compared data from the entire Korean population with the sample data. The detailed methods of these procedures were described by the National Health Insurance Sharing Service.18 This cohort database included 1) personal information, 2) health insurance claim codes (procedures and prescriptions), 3) diagnostic codes using the International Classification of Disease-10 (ICD-10), 4) socio-economic data (residence and income), and 5) medical examination data for each participant for a period ranging from 2002 to 2013.
As all Korean citizens have a 13-digit resident registration number from birth to death, exact population statistics can be determined from the database. It is mandatory for all Koreans to enroll in the NHIS. All Korean hospitals and clinics use the 13-digit resident registration number to register individual patients for the medical insurance system. Therefore, the risk of overlapping medical records is minimal, even if a patient moves from one place to another. Moreover, all medical treatments in Korea can be tracked using the HIRA system without exception.

Participants selection

From 1,025,340 cases with 114,369,638 medical claim codes, participants who received adenoidectomy (claim codes: Q2800) with/without tonsillectomy from 2004 through 2012 were included (n = 2,735). Among them, the participants who received sinus surgery such as antrostomy, endoscopic sinus surgery, or Caldwell-Luc operation were excluded (n = 12). They were 1:4 matched with the participants (control group) who never received adenoidectomy from 2002 through 2013 in this cohort. Matching was processed for age group, sex, income group, region of residence, and the number of pre-operative sinusitis histories for 2 years. To prevent selection bias when selecting the matched participants, control group participants were sorted by random number order, and they were selected from top to bottom. Adenoidectomy participants who did not have enough matching participants were excluded (n = 130). Finally, we used 1:4 matching to select 2,593 adenoidectomy participants (adenoidectomy without tonsillectomy = 332 [12.6%], adenoidectomy with tonsillectomy = 2,309 [87.4%]) and 10,372 control participants (Fig. 1).
Fig. 1
Schematic illustration of participant selection for the present study. Of a total of 1,025,340 participants, 2,735 adenoidectomy participants were selected. Participants who underwent sinus surgery were excluded (n = 12). The adenoidectomy participants were matched 1:4 with controls who did not undergo adenoidectomy. Un-matched adenoidectomy participants were excluded (n = 130). Finally, 2,593 adenoidectomy participants and 10,372 control participants were included.
jkms-33-e78-g001

Variables

The age groups were classified into 5-year intervals: 0–4, 5–9, 10–14, …, and 80+ years old. Consequently, 17 age groups were designated (Age group of 0 and 1–4 were merged). The income groups were initially divided into 41 classes (one health aid class, 20 self-employment health insurance classes, and 20 employment health insurance classes). These groups were re-categorized into 11 classes (class 1 [lowest income]–11 [highest income]). Regions of residence were divided into 16 areas according to administrative district. It was regrouped as urban (Seoul, Busan, Daegu, Incheon, Gwangju, Daejeon, and Ulsan) and rural area (Gyeonggi-do, Gangwon-do, Chungcheongbuk-do, Chungcheongnam-do, Jeollabuk-do, Jeollanam-do, Gyeongsangbuk-do, Gyeongsangnam-do, and Jeju-do).
We defined sinusitis using the ICD-10 codes: J01 (acute sinusitis) and J32 (chronic sinusitis). The number of visits to clinics or hospitals for sinusitis was counted every year. Pre-operative sinusitis was counted for 2 years. Post-op sinusitis was counted each year (1, 2, 3, …, 9 years), and post-op sinusitis for total periods were calculated (Fig. 2).
Fig. 2
Schematic illustration of numbers of pre-operative and post-operative sinusitis visits. The number of visits for sinusitis were recorded for 2 years before adenoidectomy. Postoperative visits for sinusitis were counted for 1–9 years according to when the patient underwent surgery.
Pre-op = pre-operative, OP = operative.
jkms-33-e78-g002

Statistical analyses

An equivalence test was used to compare the number of sinusitis visits (pre-operative, post-op 1, 2, 3, ..., 9 years) between the adenoidectomy group and control group. The null hypothesis is that post-op sinusitis between the adenoidectomy and control group is not the same. Margin of equivalence of difference (adenoidectomy − control group) was set as −0.5 to 0.5.
For the subgroup analysis according to frequency of sinusitis, the participants were divided into 2 groups: rare pre-operative sinusitis (< 3 times for 2 years) and frequent pre-operative sinusitis (≥ 3 times for 2 years). For the subgroup analysis according to age, the participants were divided into 3 groups: 0–4, 5–9, and 10–14 years old.
For the equivalence test, 95% confidence interval (CI) of difference < 0.5 was considered to indicate statistical significance. The results were statistically analyzed using SPSS v. 21.0 (IBM, Armonk, NY, USA).

Ethics statement

The Institutional Review Board of the Hallym University (2014-I148) approved the use of these data. Written informed consent was exempted by the Institutional Review Board.

RESULTS

Because of matching, the general characteristics (age group, sex, income level, and region of residence) were equivalent in both groups (Table 1). We compared the visits for sinusitis during the follow up periods. The number of visits for pre-operative sinusitis was also exactly the same in both groups. There were trivial differences between the adenoidectomy and control group from post-op 1 to 2 years (0.3 < 95% CI of difference in post-op 1 year < 0.6; 0.2 < 95% CI of difference in post-op 2 years < 0.5). Visits for sinusitis were larger in the adenoidectomy group than control group from post-op 1 to 2 years. However, there were no differences between the adenoidectomy and control group from post-op 3 through 9 years (−0.5 < all of 95% CI of difference < 0.5). We could find that sinusitis visits gradually decreased from 4.0/2 year (pre-operative), 1.8/year (post-op 1 year), 1.6/year (post-op 2 years), 1.3/year (post-op 3 years), 1.2/year (post-op 4 years), 1.0/year (post-op 5 years), 0.9/year (post-op 6 years), 0.7/year (post-op 7 years), 0.7/year (post-op 8 years), and 0.5/year (post-op 9 years) in the adenoidectomy group. These changes were also found in the control group as the same scale (Table 2).
Table 1

General characteristics of participants

jkms-33-e78-i001
Characteristics No. of participants (1:4 matching)
Adenoidectomy group Control group Total participants
Age, yr
0–4 1,604 6,416 8,020
5–9 793 3,172 3,965
10–14 196 784 980
Sex
Male 1,610 6,440 8,050
Female 983 3,932 4,915
Income
1 (lowest) 14 56 70
2 47 188 235
3 72 288 360
4 118 472 590
5 205 820 1,025
6 252 1,008 1,260
7 346 1,384 1,730
8 413 1,652 2,065
9 425 1,700 2,125
10 389 1,556 1,945
11 (highest) 312 1,248 1,560
Region of residence
Urban 1,146 4,584 5,730
Rural 1,447 5,788 7,235
Table 2

Difference of mean values of pre-operative and post-operative sinusitis between adenoidectomy and control group

jkms-33-e78-i002
Sinusitis related history Adenoidectomy Control 95% CI of differencea P value
Pre-op sinusitis for 2 yr (n = 12,965) 4.0 ± 4.5 4.0 ± 4.5 −0.2, 0.2 1.000
Post-op 1 yr sinusitis (n = 12,965) 1.8 ± 3.4 1.4 ± 3.0 0.3, 0.6 < 0.001
Post-op 2 yr sinusitis (n = 12,395) 1.6 ± 3.6 1.3 ± 3.1 0.2, 0.5 < 0.001
Post-op 3 yr sinusitis (n = 11,595) 1.3 ± 3.1 1.1 ± 2.8 0.0, 0.3 0.011
Post-op 4 yr sinusitis (n = 10,930) 1.2 ± 3.8 1.0 ± 2.8 0.0, 0.4 0.022
Post-op 5 yr sinusitis (n = 9,830) 1.0 ± 3.5 0.9 ± 2.3 0.0, 0.3 0.087
Post-op 6 yr sinusitis (n = 8,390) 0.9 ± 3.6 0.7 ± 1.9 0.0, 0.4 0.017
Post-op 7 yr sinusitis (n = 6,460) 0.7 ± 2.1 0.6 ± 2.1 0.0, 0.2 0.160
Post-op 8 yr sinusitis (n = 4,205) 0.7 ± 2.1 0.6 ± 1.7 −0.1, 0.2 0.243
Post-op 9 yr sinusitis (n = 2,240) 0.5 ± 1.7 0.4 ± 1.3 −0.1, 0.2 0.500
Data are shown as mean ± standard deviation.
Pre-op = pre-operative, Post-op = post-operative, CI = confidence interval.
aDifference = adenoidectomy − control group.
In the rare pre-operative sinusitis group (< 3 times for 2 years), there were minor differences between the adenoidectomy and control group from post-op 1 to 2 years (0.4 < 95% CI of difference in post-op 1 year < 0.7; 0.2 < 95% CI of difference in post-op 2 years < 0.5). Additionally, there were insignificant differences between the adenoidectomy and control group from post-op 1 to 2 years in the frequent pre-operative sinusitis group (0.1 < 95% CI of difference in post-op 1 year < 0.6; 0.0 < 95% CI of difference in post-op 2 years < 0.5). Visits for sinusitis were larger in the adenoidectomy group than the control group from post-op 1 to 2 years in both the rare and frequent pre-operative sinusitis group. However, no difference of visit for sinusitis were found between the adenoidectomy and control group (−0.5 < all of 95% CI of difference < 0.5) during follow up periods from post-op 3 through post-op 9 years (Table 3).
Table 3

Subgroup analysis of mean values of pre-operative and post-operative sinusitis between adenoidectomy and control group (Rare vs. frequent pre-operative sinusitis)

jkms-33-e78-i003
Sinusitis related history Adenoidectomy Control 95% CI of differencea P value
Rare pre-operative sinusitis (< 3 times for 2 yr)
Pre-op sinusitis for 2 yr (n = 6,705) 0.7 ± 0.8 0.7 ± 0.8 0.0, 0.0 1.000
Post-op 1 yr sinusitis (n = 6,705) 1.1 ± 2.4 0.6 ± 1.6 0.4, 0.7 < 0.001
Post-op 2 yr sinusitis (n = 6,310) 1.0 ± 3.2 0.6 ± 1.8 0.2, 0.5 < 0.001
Post-op 3 yr sinusitis (n = 5,795) 0.8 ± 2.7 0.6 ± 2.0 0.0, 0.4 0.019
Post-op 4 yr sinusitis (n = 5,405) 0.8 ± 4.2 0.6 ± 2.0 0.0, 0.5 0.070
Post-op 5 yr sinusitis (n = 4,470) 0.7 ± 4.1 0.5 ± 1.6 0.0, 0.5 0.065
Post-op 6 yr sinusitis (n = 4,000) 0.7 ± 4.3 0.4 ± 1.5 0.0, 0.6 0.059
Post-op 7 yr sinusitis (n = 3,070) 0.5 ± 1.8 0.4 ± 1.5 −0.1, 0.3 0.251
Post-op 8 yr sinusitis (n = 2,085) 0.4 ± 1.3 0.4 ± 1.3 −0.1, 0.1 0.915
Post-op 9 yr sinusitis (n = 1,125) 0.4 ± 2.0 0.3 ± 1.3 −0.1, 0.3 0.483
Frequent pre-operative sinusitis (≥ 3 times for 2 yr)
Pre-op sinusitis for 2 yr (n = 6,260) 7.4 ± 4.3 7.4 ± 4.3 −0.3, 0.3 1.000
Post-op 1 yr sinusitis (n = 6,260) 2.6 ± 4.0 2.2 ± 3.9 0.1, 0.6 0.011
Post-op 2 yr sinusitis (n = 6,085) 2.2 ± 3.8 1.9 ± 3.9 0.0, 0.5 0.019
Post-op 3 yr sinusitis (n = 5,800) 1.8 ± 3.4 1.6 ± 3.4 −0.1, 0.4 0.143
Post-op 4 yr sinusitis (n = 5,525) 1.6 ± 3.3 1.4 ± 3.3 −0.1, 0.4 0.154
Post-op 5 yr sinusitis (n = 5,060) 1.3 ± 2.9 1.2 ± 2.8 −0.1, 0.2 0.651
Post-op 6 yr sinusitis (n = 4,390) 1.1 ± 2.8 0.9 ± 2.2 −0.1, 0.3 0.143
Post-op 7 yr sinusitis (n = 3,390) 0.9 ± 2.3 0.8 ± 2.3 −0.1, 0.3 0.384
Post-op 8 yr sinusitis (n = 2,120) 1.0 ± 2.6 0.8 ± 2.0 −0.1, 0.5 0.167
Post-op 9 yr sinusitis (n = 1,115) 0.5 ± 1.3 0.5 ± 1.4 −0.2, 0.2 0.811
Data are shown as mean ± standard deviation.
Pre-op = pre-operative, Post-op = post-operative, CI = confidence interval.
aDifference = adenoidectomy − control group.
In the 0–4 years old group, there were minor differences between the adenoidectomy and control group from post-op 1 to 2 years (−0.8 < 95% CI of difference in post-op 1 year < −0.4; −0.6 < 95% CI of difference in post-op 2 years < −0.2). However, no difference in the number of visits for sinusitis were found between the adenoidectomy and control group (−0.5 < all of 95% CI of difference < 0.5) during follow up periods from post-op 3 through 9 years. Additionally, there were no differences between the adenoidectomy and control group during the whole follow up period from post-op 1 through post-op 9 years (Table 4).
Table 4

Subgroup analysis of mean values of pre-operative and post-operative sinusitis between adenoidectomy and control group according to age group

jkms-33-e78-i004
Sinusitis by age Adenoidectomy Control 95% CI of differencea P value
Age (0–4 yr old)
Pre-op sinusitis for 2 yr (n = 6,705) 4.7 ± 4.9 4.7 ± 4.9 −0.3, 0.3 1.000
Post-op 1 yr sinusitis (n = 6,705) 1.1 ± 2.4 0.6 ± 1.6 −0.8, −0.4 < 0.001
Post-op 2 yr sinusitis (n = 6,310) 1.0 ± 3.2 0.6 ± 1.8 −0.6, −0.2 < 0.001
Post-op 3 yr sinusitis (n = 5,795) 0.8 ± 2.7 0.6 ± 2.0 −0.4, 0.0 0.074
Post-op 4 yr sinusitis (n = 5,405) 0.8 ± 4.2 0.6 ± 2.0 −0.4, 0.0 0.060
Post-op 5 yr sinusitis (n = 4,470) 0.7 ± 4.1 0.5 ± 1.6 −0.4, 0.0 0.018
Post-op 6 yr sinusitis (n = 4,000) 0.7 ± 4.3 0.4 ± 1.5 −0.5, 0.1 0.009
Post-op 7 yr sinusitis (n = 3,070) 0.5 ± 1.8 0.4 ± 1.5 −0.3, 0.1 0.509
Post-op 8 yr sinusitis (n = 2,085) 0.4 ± 1.3 0.4 ± 1.3 −0.4, 0.1 0.141
Post-op 9 yr sinusitis (n = 1,125) 0.4 ± 2.0 0.3 ± 1.3 −0.4, 0.2 0.525
Age (5–9 yr old)
Pre-op sinusitis for 2 yr (n = 6,260) 2.9 ± 3.7 2.9 ± 3.7 −0.3, 0.3 1.000
Post-op 1 yr sinusitis (n = 6,260) 0.9 ± 2.3 1.1 ± 1.9 −0.3, 0.0 0.022
Post-op 2 yr sinusitis (n = 6,085) 0.8 ± 2.1 1.0 ± 2.4 −0.4, 0.0 0.034
Post-op 3 yr sinusitis (n = 5,800) 0.8 ± 2.0 0.9 ± 2.3 −0.3, 0.0 0.035
Post-op 4 yr sinusitis (n = 5,525) 0.6 ± 1.6 0.8 ± 2.1 −0.4, 0.1 0.003
Post-op 5 yr sinusitis (n = 5,060) 0.6 ± 1.8 0.6 ± 2.0 −0.2, 0.1 0.726
Post-op 6 yr sinusitis (n = 4,390) 0.5 ± 1.6 0.7 ± 1.9 −0.5, 0.1 0.032
Post-op 7 yr sinusitis (n = 3,390) 0.4 ± 1.4 0.6 ± 1.8 −0.3, 0.0 0.032
Post-op 8 yr sinusitis (n = 2,120) 0.5 ± 1.6 0.4 ± 1.3 −0.2, 0.2 0.794
Post-op 9 yr sinusitis (n = 1,115) 0.3 ± 1.2 0.3 ± 0.9 0.1, 0.2 0.640
Age (10–14 yr old)
Pre-op sinusitis for 2 yr (n = 6,260) 1.7 ± 2.4 1.7 ± 2.4 −0.4, 0.4 1.000
Post-op 1 yr sinusitis (n = 6,260) 0.6 ± 1.8 0.6 ± 1.4 −0.3, 0.2 0.609
Post-op 2 yr sinusitis (n = 6,085) 0.5 ± 1.5 0.5 ± 1.3 −0.3, 0.2 0.563
Post-op 3 yr sinusitis (n = 5,800) 0.4 ± 1.4 0.5 ± 1.5 −0.4, 0.1 0.327
Post-op 4 yr sinusitis (n = 5,525) 0.4 ± 1.4 0.4 ± 1.2 −0.2, 0.2 0.927
Post-op 5 yr sinusitis (n = 5,060) 0.3 ± 1.2 0.3 ± 0.8 −0.1, 0.2 0.336
Post-op 6 yr sinusitis (n = 4,390) 0.2 ± 1.1 0.3 ± 1.0 −0.3, 0.1 0.403
Post-op 7 yr sinusitis (n = 3,390) 0.3 ± 1.6 0.2 ± 0.8 −0.1, 0.2 0.539
Post-op 8 yr sinusitis (n = 2,120) 0.2 ± 0.9 0.3 ± 1.0 −0.3, 0.1 0.240
Post-op 9 yr sinusitis (n = 1,115) 0.1 ± 0.6 0.3 ± 0.6 −0.3, 0.1 0.188
Data are shown as mean ± standard deviation.
Pre-op = pre-operative, Post-op = post-operative, CI = confidence interval.
aDifference = adenoidectomy − control group.

DISCUSSION

We could not find a definite difference of sinusitis visits between the adenoidectomy and control groups from post-op 3 through 9 years. Although visits for sinusitis were larger in the adenoidectomy group than the control group from post-op 1 to 2 years, they were not very significantly deviated in the equivalence test. After adenoidectomy, the sinusitis visits gradually decreased during follow up periods. However, this was also found in the control group on the same scale.
The latest Cochrane library review reviewed 2 randomized controlled trials (RCTs) for children.10 One study showed that improvement in frequency of nasal obstruction, meaning a change from frequent to infrequent, was found in 61% vs. 41% after 12 months, and in 63% vs. 55% after 24 months in the adenoidectomy and control groups, respectively. The risk difference was non-significant, being 20% (95% CI, −2%, 43%) and 8% (95% CI, −15%, 32%).17 The other study found that at 6 months the mean number of days with nasal discharge in children who underwent adenoidectomy was 26 as compared to 23 days in the control group. The difference was non-significant, being −4 days (95% CI, −13, 7 days).16 These studies' designs were randomized, double blind, and controlled trials. The level of evidence is higher than any other study design. In fact, the designs of studies to support the effectiveness of adenoidectomy for sinusitis were retrospective chart review8 or prospective study without control.131418
Adenoid tissue was historically regarded as a source for bacteria.814 Additionally, the effect of adenoid for sinusitis may be secondary to mechanical obstruction of the nasopharynx.4 Therefore, some authors suggested that adenoidectomy should be performed to remove mechanical obstruction of the nasopharynx or infection focus in chronic or recurrent sinusitis patients.131419 However, they had some limitations due to small participant size,1319 significant follow up loss,19 and lack of investigation about subjective sinusitis symptoms.8 Additionally, Tuncer et al.20 compared maxillary sinus aspirate cultures with adenoid tissue cultures in pediatric subjects with both chronic sinusitis and adenoid hypertrophy. There was a difference of isolated bacteria between adenoid and sinus. The most frequently isolated bacteria in the adenoid culture were Staphylococcus aureus and Streptococcus pneumoniae. The most frequently isolated bacteria in the sinus aspirate culture were α-hemolytic Streptococcus, Neisseria, and β-hemolytic Streptococcus. Thus, they concluded that adenoids did not act as a reservoir of bacteria.20 Furthermore, Berçin et al.9 demonstrated that adenoid volume is not correlated with the extent of sinusitis on paranasal sinus computed tomography scan in the pediatric patients with sinusitis.
One advantage of this study is the large number of study participants (n = 12,965). We followed the adenoidectomy group for a maximum of 9 years, while other studies were conducted for a maximum of 2 years.1317 To our knowledge, this is the largest study which evaluated the efficacy of adenoidectomy for sinusitis. Another advantage is the availability of the comprehensive medical records of each participant. Previous studies asked the participants their histories of recurrent nasal symptoms, which could produce recall bias.1719 In this study, we used their medical record for sinusitis visits using HIRA data. These recorded data were not distorted by their memories. This HIRA data include the entire nation without exception. Therefore, we did not miss any participants during follow up periods, while significant loss of follow up were problems of other studies.13171921 Even though we did not use RCT methods, we matched our participants exactly with a control group according to age, sex, income, region of residence, and previous operative sinusitis visit. Income and region matching were important in that they could be determinant factors for access to medical treatment. Income levels were determined very accurately using the Korean NHIS, given that the patient's premium is determined based on income. Our study results were representative of the entire Korean population, as the data were selected from a database covering the entire population and were verified by a statistician for representativeness. Therefore, we think that removing the adenoid is not the effective treatment in patients who present with symptoms of sinusitis. Additionally, as the children grow, the immune system comes to maturity and adenoid tissue size decrease.
Our study had several limitations. We used health insurance claim data and counted the numbers of visit for sinusitis. It did not exactly mean the number of infections. Many Korean doctors choose the ICD code for insurance coverage of their treatment under the performance-based payment system. The ICD code for sinusitis may be used for common cold patients. However, we think that the number of visits for sinusitis could be a surrogate index of the number of infections within the context of these big data. We could not measure the severity of sinusitis in each participant. The medical use of each participant could be variable in the same disease. We included the participants who received adenoidectomy with tonsillectomy for chronic tonsillar hypertrophy, in that we could not evaluate the purpose of adenoidectomy in each participant. However, if adenoidectomy could reduce sinusitis, the sinusitis of the participants who received adenoidectomy with tonsillectomy for chronic tonsillar hypertrophy also should be decreased.
In conclusion, adenoidectomy does not have a benefit for sinusitis. Sinusitis decreased over time regardless of adenoidectomy.

Notes

Funding: This work was supported by the National Research Foundation of Korea (Grant number: NRF-2015R1D1A1A01060860, NRF-2017R1C1B1008842).

Disclosure: The authors have no potential conflicts of interest to disclose.

Author Contributions: Conceptualization: Choi HG. Methodology: Kim SY, Choi HG. Formal analysis: Choi HG. Writing - original draft: Kim MS.

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ORCID iDs

Min-Su Kim
https://orcid.org/0000-0001-8311-4174

So Young Kim
https://orcid.org/0000-0002-7361-4930

Hyo Geun Choi
https://orcid.org/0000-0003-1655-9549

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