Non-Operative Management of Musculoskeletal Diseases and Regenerative Medicine

Joo Han Oh; Sung-Min Rhee

doi:10.4055/jkoa.2018.53.5.375

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Oh and Rhee: Non-Operative Management of Musculoskeletal Diseases and Regenerative Medicine

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Non-Operative Regenerative Therapy for Musculoskeletal Disorders

Journal of the Korean Orthopaedic Association 2018; 53(5): 375-380.

Published online: 31 October 2018

DOI: https://doi.org/10.4055/jkoa.2018.53.5.375

Non-Operative Management of Musculoskeletal Diseases and Regenerative Medicine

Joo Han Oh, M.D., Ph.D., Sung-Min Rhee, M.D.

Department of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Correspondence to: Sung-Min Rhee, M.D. Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 13620, Korea. TEL: +82-31-787-7197, FAX: +82-31-787-4056, starsmstar@daum.net

Received 24 November 2017 Revised 8 May 2018 Accepted 23 May 2018

The Korean Orthopaedic Association

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recently, due to the unsatisfactory outcomes of several orthopedic surgical procedures, non-operative management of musculoskeletal diseases, including regenerative medicine, is becoming more attractive to orthopedic surgeons. Regarding the healing of musculoskeletal tissues, such as bone, cartilage and tendons, regenerative medicine aims to replace or promote tissue regeneration. Among them, therapy using stem cells, prolotherapy, platelet-rich plasma, and extracorporeal shockwave therapy are taking center stage. Numerous animal and clinical studies have been published and the number has increased exponentially in recent years. On the other hand, because regenerative medicine in the orthopedic field is still in the early stages, no definite methods for the procedures have been made and there is some controversy regarding their application to musculoskeletal disease. Therefore, more high quality studies including randomized studies should be performed to establish standards and evaluate their value in the orthopedic field.

Keywords: regenerative medicine, stem cell, prolotherapy, platelet-rich plasma, extracorporeal shockwave therapy

Notes

^{CONFLICTS OF INTEREST} The authors have nothing to disclose.

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ORCID iDs: Sung-Min Rhee
https://orcid.org/0000-0002-7087-4219
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