A review of biocompatibility of zirconia: In vitro experiment

Da-Won Suh; Young-Kyun Kim; Yang-Jin Yi

doi:10.4047/jkap.2018.56.4.391

Journal List > J Korean Acad Prosthodont > v.56(4) > 1106326

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Suh, Kim, and Yi: A review of biocompatibility of zirconia: In vitro experiment

Review Article

J Korean Acad Prosthodont 2018;56(4):391-395.

Published online: NaN October 2018

DOI: https://doi.org/10.4047/jkap.2018.56.4.391

A review of biocompatibility of zirconia: In vitro experiment

Da-Won Suh¹, Young-Kyun Kim², Yang-Jin Yi^3,^∗

^¹School of Dentistry, Seoul National University, Seoul, Republic of Korea

^²Department of Oral & Maxillofacial Surgery, Seoul National University Bundang Hospital, Seongnam, School of Dentistry, Seoul National University, Seoul, Republic of Korea

^³Department of Prosthodontics, Seoul National University Bundang Hospital, Seongnam, School of Dentistry, Seoul National University, Seoul, Republic of Korea

∗Corresponding Author: Yang-Jin Yi Department of Prosthodontics, Seoul National University Bundang Hospital 82 Gumi-ro 173-gil, Bundang-gu, Seongnam 13620, Republic of Korea +82 (0)31 787 7546: e-mail, navydent@snubh.org

Received 19 September 201810 October 2018 Accepted 19 October 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Increasing demands for zirconia material in clinics, assessment of biocompatibility of zirconia is essential. In this article, a review of in vitro studies of zirconia compatibility was performed. Zirconia showed great biocompatibility at in vitro studies with various cell lines such as fibroblasts, osteoblasts, and lymphocytes. Many studies reported that zirconia caused no cytotoxicity or mutation. Zirconia also showed less bacterial adhesion. There were no adverse effects except for small reduced strength with in vitro study mimicking long-term exposure of body fluid. According to the study with ostoblast-like cells, zirconia could regulate genes of immunity, molecular transport, and cell cycle. Such gene regulating was considered as one of the reasons of zirconia biocompatibility. With biocompatibility of zirconia powders, in vitro studies had controversial conclusions. It seems that zirconia powders might have cytotoxicity. (J Korean Acad Prosthodont 2018;56:391-5)

Keywords: Biocompatibility, Cytotoxicity, Zirconia

REFERENCES

1.Kosmac T., Oblak C., Jevnikar P., Funduk N., Marion L. The effect of surface grinding and sandblasting on flexural strength and reliability of Y-TZP zirconia ceramic. Dent Mater. 1999. 15:426–33.

2.Al-Amleh B., Lyons K., Swain M. Clinical trials in zirconia: a systematic review. J Oral Rehabil. 2010. 37:641–52.

3.Manicone PF., Rossi Iommetti P., Raffaelli L., Paolantonio M., Rossi G., Berardi D., Perfetti G. Biological considerations on the use of zirconia for dental devices. Int J Immunopathol Pharmacol. 2007. 20:9–12.

4.Josset Y., Oum'Hamed Z., Zarrinpour A., Lorenzato M., Adnet JJ., Laurent-Maquin D. In vitro reactions of human osteoblasts in culture with zirconia and alumina ceramics. J Biomed Mater Res. 1999. 47:481–93.

5.Fassina P., Zaghini N., Bukat A., Piconi C., Greco F., Piantelli S. Yttria and calcia partially stabilized zirconia for biomedical applications. Ravaglioli A., Krajewski A, editors. Bioceramics and the human body. Netherlands: Springer;1992. p. 223–9.

6.Silva VV., Lameiras FS., Lobato ZI. Biological reactivity of zirconia-hydroxyapatite composites. J Biomed Mater Res. 2002. 63:583–90.

7.Carinci F., Pezzetti F., Volinia S., Francioso F., Arcelli D., Farina E., Piattelli A. Zirconium oxide: analysis of MG63 osteoblast-like cell response by means of a microarray technology. Biomaterials. 2004. 25:215–28.

8.Garvie RC., Urbani C., Kennedy DR., McNeuer JC. Biocompatibility of Magnesia Partially Stabilized Zirconia (Mg-PSZ) Ceramics. J Mater Sci. 1984. 19:3224–8.

9.Rimondini L., Cerroni L., Carrassi A., Torricelli P. Bacterial colonization of zirconia ceramic surfaces: an in vitro and in vivo study. Int J Oral Maxillofac Implants. 2002. 17:793–8.

10.Covacci V., Bruzzese N., Maccauro G., Andreassi C., Ricci GA., Piconi C., Marmo E., Burger W., Cittadini A. In vitro evaluation of the mutagenic and carcinogenic power of high purity zirconia ceramic. Biomaterials. 1999. 20:371–6.

11.Ito A., Tateishi T., Niwa S., Tange S. In-vitro evaluation of the cytocompatibility of wear particles generated by UHMWPE/zirconia friction. Clin Mater. 1993. 12:203–9.

12.Catelas I., Petit A., Zukor DJ., Marchand R., Yahia L., Huk OL. Induction of macrophage apoptosis by ceramic and polyethylene particles in vitro. Biomaterials. 1999. 20:625–30.

13.Li J., Liu Y., Hermansson L., Söremark R. Evaluation of biocompatibility of various ceramic powders with human fibroblasts in vitro. Clin Mater. 1993. 12:197–201.

14.Nkamgueu EM., Adnet JJ., Bernard J., Zierold K., Kilian L., Jal-lot E., Benhayoune H., Bonhomme P. In vitro effects of zirconia and alumina particles on human blood monocyte-derived macrophages: X-ray microanalysis and flow cytometric studies. J Biomed Mater Res. 2000. 52:587–94.

15.Dion I., Rouais F., Baquey C., Lahaye M., Salmon R., Trut L., Cazorla JP., Huong PV., Monties JR., Havlik P. Physico-chemistry and cytotoxicity of ceramics: part I: characterization of ceramic powders. J Mater Sci Mater Med. 1997. 8:325–32.

16.Lohmann CH., Dean DD., Köster G., Casasola D., Buchhorn GH., Fink U., Schwartz Z., Boyan BD. Ceramic and PMMA particles differentially affect osteoblast phenotype. Biomaterials. 2002. 23:1855–63.

17.Sterner T., Schütze N., Saxler G., Jakob F., Rader CP. Effects of clinically relevant alumina ceramic, zirconia ceramic and titanium particles of different sizes and concentrations on TNF-alpha release in a human macrophage cell line. Biomed Tech (Berl). 2004. 49:340–4.

18.Tateishi T., Ushida T., Aoki H. Round robin test for standardization of biocompatibility test procedure by cell culture method. Adv Biomater. 1992. 10:89–97.

TOOLS

Similar articles