Novel Therapeutic Target of Non-alcoholic Fatty Liver Disease: Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 and Reactive Oxygen Species in Pro-inflammatory Macrophages

Hyuk Soo Eun

doi:10.4166/kjg.2018.72.4.226

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Eun: Novel Therapeutic Target of Non-alcoholic Fatty Liver Disease: Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 and Reactive Oxygen Species in Pro-inflammatory Macrophages

Research Update

The Korean Journal of Gastroenterology 2018; 72(4): 226-227.

Published online: 30 October 2018

DOI: https://doi.org/10.4166/kjg.2018.72.4.226

Novel Therapeutic Target of Non-alcoholic Fatty Liver Disease: Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 and Reactive Oxygen Species in Pro-inflammatory Macrophages

Hyuk Soo Eun

Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.

Correspondence to: Hyuk Soo Eun, Department of Internal Medicine, Chungnam National University College of Medicine, 266 Munhwa-ro, Jung-gu, Daejeon 35015, Korea. Tel: +82-42-280-7418, Fax: +82-42-257-5753, hyuksoo@cnuh.co.kr

Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Notes

^{Financial support} None.

^{Conflict of interest} None.

References

1. Kim SY, Jeong JM, Kim SJ, et al. Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex. Nat Commun. 2017; 8:2247.

2. Del Ben M, Polimeni L, Carnevale R, et al. NOX2-generated oxidative stress is associated with severity of ultrasound liver steatosis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol. 2014; 14:81.

3. dela Peña A, Leclercq IA, Williams J, Farrell GC. NADPH oxidase is not an essential mediator of oxidative stress or liver injury in murine MCD diet-induced steatohepatitis. J Hepatol. 2007; 46:304–313.

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ORCID iDs: Hyuk Soo Eun
https://orcid.org/0000-0003-0485-0072
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