The purpose of this study is to grasp the attitude among personnels and to investigate the factors influencing the attitude about the operation of computer system in a new hospitals. Data was collected from 234 employees of two general hospital located in Seoul and Kyung-Ki Do, Korea, using a self-administered questionnaire. Self-administered questionnaire were given to study socioeconomic characteristics, the level of knowledge, aptitude, attitude and behavior of computerization about the operation of computer system in a new hospitals. The major findings were as follows; 1. Job position had not statistically significant relationship with the attitude about the operation of computer system. But according to age, sex, aptitude, the level of attitude about the operation of computer system was statistically significant relationships. 2. Generally, those who were had higher period of computer usage and frequency of computer education showed a higher positive attitude about the operation of computer system. Also, those who answers to improve of efficiency and satisfaction of computer system showed a higher positive attitude about the operation of computer system. 3. In the results of multiple regression, the period of computer usage, satisfaction of computer system and sex were significantly related to attitude about the operation of computer system. Also, those with good aptitude were significantly related to attitude about the operation of computer system. However, job position and duration of work was not statistically significant relationship with attitude about the operation of computer system.