This study was conducted to develop a web-based instruction program for nurses caring patients with open heart surgery. Actually, the web-based instruction program was developed for the purpose of improving knowledge and problem solving skills among nurses for intensive care units. Also, I hope this program will be used as a tool of continuing education program for nurses and contributed to the building of life-time learning system focused on advanced nursing practice. Based on the Instructional Systems Development(ISD) model and the model of Web-Based Instruction(WBI) developmental process by Chang(1998), this study was conducted from May, 1998 to May, 1999 with the five steps: analysis, design, data collection and reconstruction, programming and publishing, and evaluation steps.