The purpose of this study was to explore the nurse satisfaction on changed job process after acquiring Ward- OCS, and offer the data for the strategy of information system applying to organization, the evaluation of medical information system. The data was collected from 214 nurses which using the medical information system, a self-reported survey questionnaire. The results were as follows Age, total career, current ward career, top management support was represented higher relation (r=0.240, 0.235, 0.247, 0.212, p < .01) with job satisfaction. add to that, IT, executives support, organizational alignment experience of computer education was significant(r=0.172, 0.207, 0.135, 0.155, p < .05)In conclusion, for effective using of information system, the proceeding is to be in the middle of ward career nurse, pre-computer education is recommended, and ongoing top management support and IT executives support with linking the ward job is necessary.