This study intended to examine the effect of pamidronate, when it was administrated in early estrogen deficiency period, by examining biomechanically bone mass generated in trunkal and extremity bone with bone strength examination.

17-weeks-old 95 mice of Sprague-Dawley lines were divided into 1st group 28mice, 2nd group 25mice and 3rd group 42mice. The 1st group was sham-operated group, 2nd group underwent bilateral ovariectomy and then injected intravenously normal saline 0.05cc, and 3rd group underwent bilateral ovariectomy and then injected intravenously pamidronate 0.1mg/Kg.

The strength of femur, tibia and spine was surveyed with Young' modulus. Femur and spine had a statistically significant difference between 1 and 2 group, 2 and 3 group, and tibia had between 2 and 3 group.

In early osteoporosis, pamidronate administration is supposed to prevent or decrease osteoporosis and fracture resulting from osteoporosis.