Cyberspace be comes one of the most influential media for the formation of sexual identity, knowledge , and attitude of the adolesc ents. Online sex education program may help the adolescents the sexual development processes e fficiently and confidentially. Most of the online sex education programs are not truly interactive nor adaptive. Didactic education materials may not be sufficient to modify adolescents online sexual activities. Computer-patient dialogue programs can help to develop truly intera ctive online contents that adaptively a ccommoda te the persona lized needs of the adolescents. This paper describes the development and implementation technology of a Web-based dialogue system for the interactive online sex education. A threetiered database-backed Web system with browser-based dialogue editor, automatic script-code generator, automatic relationaldatabase schema genera tor, and integrated program development environment was produced and tested on the online sex education program. The Web dialogue system can also be used for online surveys, clinical trials, and electronic medical records. This approa ch can enhance collabor ation betwe en the consumer-or iented and the provider-oriented informa tion systems.