Several years has passed to begin a new paradigm, job separation of a physician and a pharmaceutist, and a electronic prescription becomes common in large scale hospitals. However, the current prescription information system retains some problems such as insufficient patient usability, labor saving techniques and security. This paper is addressed to implement a voice prescription service system to solve the preceding problems. Several suggestions are presented to use voice recognition, voice compression, computer telephony and fingerprint authentication technology for the problems. Lab experimental results show that the processing time to identify drug items is reduced by 80% compared with conventional mouse usage and voice recording is more effective to direct drug usage in a complicated prescriptions. Online fingerprint authentication furnishes evidence of a patient permission and a physician prescription. This feature provides safer security than the current security system.