Journal List > Allergy Asthma Respir Dis > v.6(5) > 1102175

Allergy Asthma Respir Dis. 2018 Sep;6(5):237-240. Korean.
Published online September 28, 2018.
© 2018 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology
Proper allergen selection for serum specific IgE test in children
Yong Ju Lee,1 Hyeon-Jong Yang,2 Jong-Seo Yoon,3 Man-Yong Han,4 Chang Keun Kim,5 Jin Tack Kim,3 and the Korean Academy of Pediatric Allergy and Respiratory Disease Research Executive Committee
1Department of Pedaitrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.
2Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea.
3Department of Pediatrics, College of Medicine, The Catholic University, Seoul, Korea.
4Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Bundang, Korea.
5Department of Pediatircs, Inje University Sanggye Paik Hospital, Seoul, Korea.

Correspondence to: Chang-Keun Kim. Asthma and Allergy Center, Department of Pediatrics, Inje University Sanggye Paik Hospital, 1342 Dongil-ro, Nowon-gu, Seoul 01757, Korea. Tel: +82-2-950-8832, Fax: +82-2-950-1662, Email:
Received February 26, 2018; Revised April 08, 2018; Accepted April 20, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (


Identifying allergic sensitization is important for the proper diagnosis and management of allergic diseases. Skin prick testing and measuring serum specific IgE antibodies are standard tests to confirm allergic sensitization. Skin prick testing has many advantages, but it is difficult to perform on young children. Serum specific IgE can be easily performed on young children, but it can be performed only up to 12 antigens in patients younger than 6 years due to insurance coverage. Therefore, it is important to select appropriate antigens for the patients. Appropriate allergens may vary depending on the patient's age, accompanying disease, and residential area, so that detailed history taking is essential for proper allergen selection. In this review, we will discuss considerations for selecting appropriate allergens for clinicians when performing an allergy test on difficult-to-test children under 6 years of age.

Keywords: Allergens; Atopic dermatitis; Allergic rhinitis; Asthma


Table 1
Allergens for allergic test in infant and preschool children
Click for larger imageClick for full tableDownload as Excel file

1. Song TW, Kim KW, Kim WK, Kim JH, Kim HH, Park YM, et al. Guidelines for the oral food challenges in children. Pediatr Allergy Respir Dis 2012;22:4–20.
2. Kim WK. Diagnosis and treatment of food allergy in children. Pediatr Allergy Respir Dis 2006;16:274–283.
3. Dinakar C. Anaphylaxis in children: current understanding and key issues in diagnosis and treatment. Curr Allergy Asthma Rep 2012;12:641–649.
4. Welch K, Chokshi N, Wang J. Approach to food allergy diagnosis and management by nonspecialty practitioners. Ann Allergy Asthma Immunol 2016;116:585–588.
5. Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R, et al. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol 2008;100 3 Suppl 3:S1–S148.
6. Carr TF, Saltoun CA. Chapter 2: skin testing in allergy. Allergy Asthma Proc 2012;33 Suppl 1:6–8.
7. Hamilton RG. Clinical laboratory assessment of immediate-type hypersensitivity. J Allergy Clin Immunol 2010;125 2 Suppl 2:S284–S296.
8. Jung YH, Ko H, Kim HY, Seo JH, Kwon JW, Kim BJ, et al. Prevalence and risk factors of food allergy in preschool children in Seoul. Korean J Asthma Allergy Clin Immunol 2011;31:177–183.
9. Sicherer SH, Wood RA. American Academy of Pediatrics Section On Allergy And Immunology. Allergy testing in childhood: using allergen-specific IgE tests. Pediatrics 2012;129:193–197.
10. Hill DA, Spergel JM. The atopic march: critical evidence and clinical relevance. Ann Allergy Asthma Immunol 2018;120:131–137.
11. Kulig M, Bergmann R, Klettke U, Wahn V, Tacke U, Wahn U. Natural course of sensitization to food and inhalant allergens during the first 6 years of life. J Allergy Clin Immunol 1999;103:1173–1179.
12. Kim HY, Shin YH, Yum HY, Jee HM, Jang SJ, Yoon JW, et al. Patterns of sensitisation to common food and inhalant allergens and allergic symptoms in pre-school children. J Paediatr Child Health 2013;49:272–277.
13. Kim NY, Kim GR, Kim JH, Baek JH, Yoon JW, Jee HM, et al. Food allergen sensitization in young children with typical signs and symptoms of immediate-type food allergies: a comparison between monosensitized and polysensitized children. Korean J Pediatr 2015;58:330–335.
14. Kim J, Hahm MI, Lee SY, Kim WK, Chae Y, Park YM, et al. Sensitization to aeroallergens in Korean children: a population-based study in 2010. J Korean Med Sci 2011;26:1165–1172.
15. Kim HY, Seo JH, Jung YH, Lee E, Yang SI, Ha M, et al. Sensitization rates to inhalant allergens in children and adolescents of Incheon and Asan area and the relationship between polysensitization and prevalence of allergic diseases. Allergy Asthma Respir Dis 2013;1:41–49.
16. Kim HY, Shin YH, Han MY. Determinants of sensitization to allergen in infants and young children. Korean J Pediatr 2014;57:205–210.
17. Yoon JW, Lee SM, Kim JH, Kim NY, Baek JH, Baek HS, et al. Sensitization patterns to common allergens in Korean children younger than 6 years of age presenting with typical symptoms or signs of allergic diseases: a single center study. Allergy Asthma Respir Dis 2014;2:272–276.
18. Song A, Lee JY, Yang HK, Kim M, Ahn K, Lee SI, et al. Sensitization in children with atopic dermatitis: a single center study. Allergy Asthma Respir Dis 2016;4:290–295.
19. Kim DH, Park YS, Jang HJ, Kim JH, Lim DH. Prevalence and allergen of allergic rhinitis in Korean children. Am J Rhinol Allergy 2016;30:72–78.
20. Lee SY, Kim KE, Pyun BY, Ahn K, Kim HH, Kim JH, et al. In: Research for prevention of food allergy. Research Report for Ministry of Food and Drug Safety. Cheongju (Korea): Ministry of Food and Drug Safety; 2015.
21. Kim Y, Seo JH, Kwon JW, Lee E, Yang SI, Cho HJ, et al. The prevalence and risk factors of allergic rhinitis from a nationwide study of Korean elementary, middle, and high school students. Allergy Asthma Respir Dis 2015;3:272–280.
22. Choi MH, Kwon EM, Kim HB, Kim CK. Sensitization to inhalant allergens and its association with allergic diseases in preschool children. Korean J Asthma Allergy Clin Immunol 2012;32:176–182.
23. Kwon SE, Lim DH, Kim JH, Son BK, Park YS, Jang HJ, et al. Prevalence and allergens of allergic rhinitis in children and adolescents in Gwangju. Allergy Asthma Respir Dis 2015;3:54–61.
24. Chiu CY, Huang YL, Tsai MH, Tu YL, Hua MC, Yao TC, et al. Sensitization to food and inhalant allergens in relation to atopic diseases in early childhood: a birth cohort study. PLoS One 2014;9:e102809
25. Kjaer HF, Eller E, Andersen KE, Høst A, Bindslev-Jensen C. The association between early sensitization patterns and subsequent allergic disease. The DARC birth cohort study. Pediatr Allergy Immunol 2009;20:726–734.