Proper allergen selection for serum specific IgE test in children

Yong Ju Lee; Hyeon-Jong Yang; Jong-Seo Yoon; Man-Yong Han; Chang Keun Kim; Jin Tack Kim

doi:10.4168/aard.2018.6.5.237

Journal List > Allergy Asthma Respir Dis > v.6(5) > 1102175

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Lee, Yang, Yoon, Han, Kim, Kim, and the Korean Academy of Pediatric Allergy and Respiratory Disease Research Executive Committee: Proper allergen selection for serum specific IgE test in children

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Allergy Asthma Respir Dis 2018;6(5):237-240.

Published online: 5 September 2018

DOI: https://doi.org/10.4168/aard.2018.6.5.237

Proper allergen selection for serum specific IgE test in children

Yong Ju Lee¹, Hyeon-Jong Yang², Jong-Seo Yoon³, Man-Yong Han⁴, Chang Keun Kim⁵, Jin Tack Kim³; the Korean Academy of Pediatric Allergy and Respiratory Disease Research Executive Committee

¹Department of Pedaitrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea

²Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea

³Department of Pediatrics, College of Medicine, The Catholic University, Seoul, Korea

⁴Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Bundang, Korea

⁵Department of Pediatircs, Inje University Sanggye Paik Hospital, Seoul, Korea

Correspondence to: Chang-Keun Kim https://orcid.org/0000-0003-4119-2849 Asthma and Allergy Center, Department of Pediatrics, Inje University Sanggye Paik Hospital, 1342 Dongil-ro, Nowon-gu, Seoul 01757, Korea Tel: +82-2-950-8832, Fax: +82-2-950-1662, E-mail: kimck@paik.ac.kr

Received 26 February 20188 April 2018 Accepted 20 April 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Identifying allergic sensitization is important for the proper diagnosis and management of allergic diseases. Skin prick testing and measuring serum specific IgE antibodies are standard tests to confirm allergic sensitization. Skin prick testing has many advantages, but it is difficult to perform on young children. Serum specific IgE can be easily performed on young children, but it can be performed only up to 12 antigens in patients younger than 6 years due to insurance coverage. Therefore, it is important to select appropriate antigens for the patients. Appropriate allergens may vary depending on the patient's age, accompanying disease, and residential area, so that detailed history taking is essential for proper allergen selection. In this review, we will discuss considerations for selecting appropriate allergens for clinicians when performing an allergy test on difficult-to-test children under 6 years of age.

Keywords: Allergens, Atopic dermatitis, Allergic rhinitis, Asthma

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Table 1.

Allergens for allergic test in infant and preschool children

Food allergy/atopic dermatitis	Wheezing/allergic (<3 yr)	Wheezing/allergic rhinitis hinitis (3–5 yr)
Egg white	D. pteronyssinus	D. pteronyssinus
Milk	D. farinae	D. farinae
Walnut	Egg white	Cat dander
Wheat	Milk	Dog dander
Peanut	Peanut	Altenaria alternata
Soybean	Soybean	Mold mix (Mx1)
Shrimp	Wheat	Cockroach
Buckwheat	Buckwheat	Oak
Fish (Cod)	Cat dander	Tree pollen mixture (Tx9)
Meat mixture (Fx73)	Dog dander	Grasss pollen mixture (Gx2)
D. pteronyssinus	Mold mix (Mx1)	Weed pollen mixture (Wx1)
D. farinae	Wee pollen mixture	(Wx1) Japanese hop

D. pteronyssinus, Dermatophagoides pteronyssinus; D. farinae, Dermatophagoides farinae.

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