Journal List > Allergy Asthma Respir Dis > v.6(5) > 1101789

Kim, Lee, Choi, Kim, Hyun, and Choi: Radiocontrast media-induced acute generalized exanthematous pustulosis: A safe administration of alternative radiocontrast media using patch tests


Acute generalized exanthematous pustulosis (AGEP) is rarely caused by radiocontrast media (RCM). The role of skin tests for the diagnosis and evaluation of cross-reactivity in a delayed type of RCM-induced hypersensitivity have yet to be determined. Here, we report a case of iodixanol-induced AGEP where we safely administered alternative RCM using patch tests. A 44-year-old woman had coronary artery angiography (CAG) for the evaluation of ischemic heart disease. She was on regular hemodialysis because of end-stage renal disease. She was given iodixanol (Visipaque) during CAG. Approximately 1 day after CAG, she developed AGEP. The patient was rehospitalized for CAG again after 1 year. We performed skin tests to choose safe alternative RCM. Intradermal tests with iodixanol, iohexol (Bonorex) and Iopamidol (Pamiray) showed negative responses. Patch tests showed a positive response to iodixanol, equivocal to iohexol, and negative to Iopamidol. We finally chose Iopamidol and performed CAG successfully without any adverse reaction. Patch tests may be a useful tool for the diagnosis and choice of safe alternatives in RCM-induced delayed-type hypersensitivity reactions such as AGEP.

Figures and Tables

Fig. 1

Generalized exanthematous rash with numerous small pustules was shown 1 day after coronary angiography using iodixanol (Visipaque, GE Healthcare, Chicago, IL, USA).

Fig. 2

Skin punch biopsy shows microabscess in horny layer of epidermis and infiltration of eosinophils in the upper dermis (H&E, ×100).

Fig. 3

Patch tests show positive response to iodixanol, equivocal response to iohexol, and negative response to iopamidol 96 hours after patch application.



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Jeong-Hee Choi

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