A Successful Pregnancy and Delivery after Heart Transplantation: The First Case Report from Korea

Hyo-In Choi; Jung Ae Hong; Min-Seok Kim; Sang Eun Lee; Sung-Ho Jung; Hye-Sung Won; Jae-Joong Kim

doi:10.4285/jkstn.2018.32.3.69

Journal List > J Korean Soc Transplant > v.32(3) > 1101780

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Choi, Hong, Kim, Lee, Jung, Won, and Kim: A Successful Pregnancy and Delivery after Heart Transplantation: The First Case Report from Korea

Case Report

J Korean Soc Transplant 2018;32(3):69-73.

Published online: 19 January 2018

DOI: https://doi.org/10.4285/jkstn.2018.32.3.69

A Successful Pregnancy and Delivery after Heart Transplantation: The First Case Report from Korea

Hyo-In Choi, M.D.¹, Jung Ae Hong, M.D.¹, Min-Seok Kim, Ph.D.¹, Sang Eun Lee, Ph.D.¹, Sung-Ho Jung, Ph.D.², Hye-Sung Won, Ph.D.³, Jae-Joong Kim, Ph.D.^1,

¹Division of Cardiology, Department of Internal Medicine Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

²Departments of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

³Departments of Thoracic and Cardiovascular Surgery, Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Corresponding author: Jae-Joong Kim Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Tel: 82-2-3010-3154, Fax: 82-2-486-5918 E-mail: jjkim@amc.seoul.kr

Received 9 May 2018 Revised 22 June 2018 Accepted 22 June 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pregnancy following heart transplantation is a high-risk condition, requiring adequate maintenance of immunosuppressive drugs that enable proper graft function for optimal maternal and fetal outcomes. Here, we present the first case of successful child delivery in a patient who underwent heart transplantation in Korea. The 35-year-old female patient had become pregnant at 4 years after heart transplantation. The pregnancy progressed uneventfully, and the infant was healthy.

Keywords: Heart transplantation, Pregnancy, Delivery, Immunosuppressant

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Table 1.

The immunosuppressive concentrations and doses, and cardiac function during pregnancy

	Pre-pregnancy	First trimester	Second trimester	Third trimester	Post-partum
Tacrolimus blood level (ng/mL)	7.3	5.9	5.7	6	8.6
Tacrolimus dose (mg/day)	5	6	9	9	3
LVEF (%)	65	60	64	70

Abbreviation: LVEF, left ventricular ejection fraction.

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