Journal List > Ann Clin Microbiol > v.21(3) > 1101265

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Sung, Kim, Yong, Lee, Lee, Lee, Chae, Lee, and Helicobacter Study Group: Multicenter Study on the Association of Positive Helicobacter pylori Stool Antigen to Anemia in Children
Original Article

Annals of Clinical Microbiology 2018; 21(3): 58-63.

Published online: 20 September 2018

DOI: https://doi.org/10.5145/ACM.2018.21.3.58

Multicenter Study on the Association of Positive Helicobacter pylori Stool Antigen to Anemia in Children

Heungsup Sung1, Mi-Na Kim1, Dongeun Yong2, Miae Lee3, Jongwook Lee4, 5, Mi-Kyung Lee6, Hiun Suk Chae7, Hae Kyung Lee8; Helicobacter Study Group

1Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

2Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.

3Department of Laboratory Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea.

4Department of Laboratory Medicine, Konyang University Hospital, Daejeon, Korea.

5Department of Laboratory Medicine, Jincheon Sungmo Hospital, Jincheon, Korea.

6Department of Laboratory Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.

7Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.

8Department of Laboratory Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.

Correspondence: Hae Kyung Lee, Department of Laboratory Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 271 Cheonbo-ro, Uijeongbu 11765, Korea. (Tel) 82-31-820-3959, (Fax) 82-31-847-6266, hkl@catholic.ac.kr

Correspondence: Mi-Na Kim, Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. (Tel) 82-2-3010-4511, (Fax) 82-2-478-0884, mnkim@amc.seoul.kr

Received 11 March 2018       Revised 22 July 2018       Accepted 29 July 2018

© 2018 The Korean Society of Clinical Microbiology

The Korean Society of Clinical Microbiology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Helicobacter pylori infection in children causes gastrointestinal symptoms and iron deficiency anemia. This study aimed to investigate trends in H. pylori stool antigen (HpSA) positivity in children and the relationship between HpSA test results and anemia.

Methods

We analyzed the results of 2,762 HpSA tests and the correlation of hemoglobin and ferritin with HpSA in patients aged 0–18 years from 2008 to 2014 at a tertiary care center. Additionally, we prospectively evaluated HpSA test results and correlation with hemoglobin in 352 specimens obtained from five centers.

Results

From 2008-2014, the mean positive rate of the HpSA test was 5.8%, with a high of 9.1% in 2012 and a low of 2.3% in 2013. The positive rate correlated with age: 2.9% in 0–6-year-olds, 5.8% in 7–12-year-olds, and 10.6% in 13–18-year-olds (P<0.0001). There was no difference in HpSA positivity in patients with (7.0%) and without (5.7%) anemia. Ferritin was significantly lower in patients with positive HpSA results than in those with negative results (P=0.0001). In a multicenter study, the positive rate of HpSA was 16.8%.

Conclusion

The rate of HpSA positivity was 5.8% in pediatric patients at a single center from 2008–2014, and this rate increased with age. Helicobacter pylori infection may be associated with iron deficiency, as ferritin level was significantly lower in HpSA-positive patients than HpSA-negative patients.

Keywords: Anemia, Ferritin, Helicobacter pylori, Hemoglobin, Stool antigen

Figures and Tables

Fig. 1

Helicobacter pylori stool antigen result by age from 2008 to 2014 in a tertiary care hospital. H. pylori stool antigen was tested by ELISA.

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Table 1

Positive and equivocal rate of Helicobacter pylori stool antigen by ELISA test from 2008 to 2014 in a tertiary care hospital

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Table 2

Positive rate of Helicobacter pylori stool antigen by immunochromatographic test of 5 hospitals in 2015

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Abbreviations: S, Severance Hospital; E, Ewha Womans University Mokdong Hospital; C, Chung-Ang University Hospital; U, Uijeongbu St. Mary's Hospital; J, Jincheon Sungmo Hospital.

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