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Abstract
Purpose:
Urogenital tuberculosis (UGT) is rarely reported in developed countries. This study evaluated the genetic susceptibility of Korean patients to UGT.
Materials and Methods:
A total of 35 UGT patients who were confirmed pathologically, 44 intrapulmonary tuberculosis (IPT) patients who were confirmed radiologically, and 102 controls over a 6 year period were enrolled in this study. The region of rs2243268 in interleukin-4 (IL-4) gene was amplified from whole blood samples, and the DNA sequences were read using the Sanger method.
Results:
Twenty women and 15 men were diagnosed with UGT. The occurrence of the CC, AC, and AA genotypes of rs2243268 were 26 (74.3%), 8 (22.9%), and 1 (2.9%), respectively, in UGT; 28 (63.6%), 15 (34.1%), and 1 (2.3%), respectively, in IPT; and 51 (50.0%), 45 (44.1%), and 6 (5.9%), respectively, in the control groups (p=0.115). The bivariate data of CC and AC/AA were 74.3% and 25.7% in UGT, 63.6% and 36.4% in IPT, and 50.0% and 50.0% in the control groups, respectively (p=0.029). The UGT was significantly different from the control group among the three genotypes (p=0.038, Fisher's exact test) and bivariate genotypes (p=0.017, Fisher's exact test). In addition, people carrying the CC genotype had a higher risk of UGT (odds ratios, 2.889; 95% confidence intervals, 1.233-6.770; p=0.015).
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Fig. 1.
Single nucleotide polymorphism in rs2243268. Sequencing chromatogram revealed the CC genotype (left), C/A genotype (middle), and AA genotype (right).
Fig. 2.
Significant differences in bivariate genotypes were observed between the urogenital tuberculosis (UGT) and the control group (p=0.017, Fisher's exact test). People carrying the CC genotype of rs2243268 had an increased risk of UGT (odds ratios, 2.889; 95% confidence intervals, 1.233-6.770; p=0.015) compared to those with the CA/AA genotypes. SNP: single-nucleotide polymorphism, IPT: intrapulmonary tuberculosis.
Table 1.
Clinical characteristics and genotype distribution of the rs2243268 polymorphism among urogenital tuberculosis (UGT), intrapulmonary tuberculosis (IPT), and control groups
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