Hippocampal Atrophy and Psychotic Symptoms in Patients with Alzheimer's Disease

Hee Jeong Jeong; Young Min Lee; Je Min Park; Byung Dae Lee; Eun Soo Moon; Soo Yeon Kim; Kang Yoon Lee; Ji-Hoon Kim; Young-In Chung

doi:10.4306/jknpa.2018.57.3.261

Journal List > J Korean Neuropsychiatr Assoc > v.57(3) > 1100328

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Jeong, Lee, Park, Lee, Moon, Kim, Lee, Kim, and Chung: Hippocampal Atrophy and Psychotic Symptoms in Patients with Alzheimer's Disease

Original Article

Journal of Korean Neuropsychiatric Association 2018; 57(3): 261-265.

Published online: 29 August 2018

DOI: https://doi.org/10.4306/jknpa.2018.57.3.261

Hippocampal Atrophy and Psychotic Symptoms in Patients with Alzheimer's Disease

Hee Jeong Jeong, MD¹, Young Min Lee, MD, PhD^1,², Je Min Park, MD, PhD¹, Byung Dae Lee, MD, PhD¹, Eun Soo Moon, MD, PhD¹, Soo Yeon Kim, MD¹, Kang Yoon Lee, MD¹, Ji-Hoon Kim, MD, PhD³, Young-In Chung, MD, PhD³

¹Department of Psychiatry, Pusan National University Hospital, Busan, Korea.

²Department of Medical Research Institute, Pusan National University Hospital, Busan, Korea.

³Department of Psychiatry, Yangsan Pusan National University Hospital, Yangsan, Korea.

Address for correspondence: Young Min Lee, MD, PhD. Departments of Psychiatry, Medical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan 49241, Korea. Tel +82-51-240-7301, Fax +82-51-248-3648, psyleekr@naver.com

Received 20 June 2018 Revised 9 July 2018 Accepted 10 August 2018

Korean Neuropsychiatric Association

Abstract

Objectives

This study examined the difference in the volume or thickness of the medial temporal lobe between Alzheimer's disease patients with psychosis (AD+P) and those without psychosis (AD−P).

Methods

Overall, 31 AD+P patients and 29 AD−P patients were included from the Memory impairment clinics of Pusan National University Hospital in Korea. AD+P was diagnosed according to Jeste and Finkel's proposed diagnostic criteria for psychosis of Alzheimer's disease. AD−P included AD patients with no psychotic symptoms during a 5-year follow-up period. Medial temporal volume or thickness was measured by 3-tesla MRI and freesufer analysis. Analysis of variance was used to examine the difference in the volume or thickness of medial temporal lobe between AP+P and AD−P after controlling for age, gender, education years, Clinical Dementia Rating scale-Sum of Box, and total intracranial volume.

Results

The hippocampal volume in AD+P was smaller than that in AD−P.

Conclusion

These findings suggest that AD+P is associated with a reduced hippocampal volume.

Keywords: Alzheimer's disease, Psychotic symptoms, Medial temporal lobe, Hippocampus

Figures and Tables

Table 1

Demographic and clinical characteristics of patients with AD+P and AD−P

Data are presented as the mean±standard deviation. Comparisons between groups were made with Mann-Whitney U test for continuous variables and χ² tests for discrete variables. AD+P : Alzheimer's disease with psychosis, AD−P : Alzheimer's disease without psychosis, CDR-SOB : Clinical Dementia Rating scale-Sum of Box, TIV : Total intracranial volume

Table 2

The difference on the volume (or thickness) of MTL between AD+P and AD−P

Analysis of variance was used after controlling age, gender, education, Clinical Dementia Rating scale-Sum of Box, and total intracranial volume. AD+P : Alzheimer's disease with psychosis, AD−P : Alzheimer's disease without psychosis, MTL : Medial temporal lobe

Notes

^{Conflicts of Interest} The authors have no financial conflicts of interest.

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