Journal List > Korean Circ J > v.48(9) > 1100161

Kook, Yu, Lee, Danenberg, and Park: Successful Transcatheter Aortic Valve Replacement for Severe Aortic Regurgitation after CARVAR Operation
Transcatheter aortic valve replacement (TAVR) in aortic regurgitation (AR) has not been well established, because the absence of an anchoring point such as calcification at the annulus and leaflets is known to be an obstacle to the procedure.1)
A 79-year-old female patient had severe AR after a Comprehensive Aortic Root and VAlve Repair (CARVAR) operation presenting with worsening dyspnea (Supplementary Video 1). CARVAR operation is a valve sparing surgical technique for aortic diseases, consisting of annular and sinotubular junction (STJ) reduction with leaflet correction.2) For reduction and correction of aortic structures, specially designed outer strip ring is used in CARVAR procedure. However, this novel technique which had been criticized for safety issues comparing with the conventional valve replacement surgery was banned in South Korea since 2013.3) Due to high surgical risk (Society of Thoracic Surgeon's predicted risk of mortality score 14.756%) and frailty of the patient (clinical frailty scale of 6), heart team decided to proceed with the TAVR procedure. In preprocedural device selection, the perimeter of the annulus was 71.9 mm and the perimeter driven diameter was 22.9 mm in multi-slice computed tomography (CT) images. The diameter of STJ with outer ring was measured as 27 mm. We thought that 2 possible anchoring points were annulus and STJ with outer ring. Therefore, a 26 or 29 mm transcatheter heart valve seemed to be possible according to the conventional annular valve sizing because perimeter or diameter was on the gray zone. Considering TAVI for AR with no calcification at annulus, larger one would be better. In addition, considering the possibility that the upper part of the transcatheter heart valve is anchored to the 27 mm-sized CARVAR ring located in the STJ instead of annulus, a transcatheter heart valve of 29 or 31 mm is considered to be appropriate. Finally, we chose a 29 mm Evolut™ R valve instead of a larger sized transcatheter heart valve due to possible risk of device deformation by outer strip ring. Despite the absence of any calcification at the annulus and leaflets (Figure 1), a 29 mm CoreValve® Evolut™ R valve (Medtronic, Minneapolis, MN, USA) was successfully implanted at a slightly lower location than the usual position utilizing an outer ring used in CARVAR surgery as the landing zone (Figure 2, Supplementary Videos 2 and 3). Upper part between outflow and waist of 29 mm Evolut™ R valve was seated at the outer strip ring.
After TAVR procedure, the patient's dyspnea improved markedly. Echocardiography showed well-functioning transcatheter heart valve without any definite evidence of central AR or paravalvular leakage (Supplementary Video 4). N-terminal brain natriuretic peptides reduced from 10,027 to 2,708 pg/mL and cardiomegaly decreased (Figure 3).
These images highlight the importance of adequate anchoring points when performing TAVR for AR.4)5)

Figures and Tables

Figure 1

Pre-procedural CT findings. (A, B) No calcification of aortic leaflets and annulus. (C, D) Outer strip ring used in the CARVAR operation tightening the aorta.

CARVAR = Comprehensive Aortic Root and VAlve Repair; CT = computed tomography.
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Figure 2

Aortogram during the TAVR procedures. (A) TAVR using the outer strip ring as an anchoring point. (B) Middle part between outflow and waist of 29 mm Evolut™ R valve was seated at the outer strip ring. Arrows indicate the location of the outer strip ring used in CARVAR operation.

CARVAR = Comprehensive Aortic Root and VAlve Repair; TAVR = transcatheter aortic valve replacement.
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Figure 3

Chest radiography of pre- and post-TAVR. Cardiothoracic ratio decreased from 67.4% to 57.2%.

TAVR = transcatheter aortic valve replacement.
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Notes

Conflict of Interest H. Danenberg is a proctor for Corevalve. The other authors have no conflicts of interest to declare.

Author Contributions

  • Conceptualization: Yu CW.

  • Investigation: Lee SH.

  • Supervision: Yu CW, Danenberg H, Park SM.

  • Validation: Park SM.

  • Visualization: Kook H, Yu CW, Park SM.

  • Writing - original draft: Kook H.

  • Writing - review & editing: Yu CW.

References

1. Roy DA, Schaefer U, Guetta V, et al. Transcatheter aortic valve implantation for pure severe native aortic valve regurgitation. J Am Coll Cardiol. 2013; 61:1577–1584.
crossref
2. Hahm SY, Choo SJ, Lee JW, et al. Novel technique of aortic valvuloplasty. Eur J Cardiothorac Surg. 2006; 29:530–536.
crossref
3. Bae JM, Shin E, Heo DS. Safety of comprehensive aortic root and valve repair surgery: a retrospective outcomes research by national evidence-based health care collaborating agency, Korea. Korean Circ J. 2012; 42:769–771.
crossref
4. Dvir D, Webb J, Brecker S, et al. Transcatheter aortic valve replacement for degenerative bioprosthetic surgical valves: results from the global valve-in-valve registry. Circulation. 2012; 126:2335–2344.
5. Webb JG, Htun N. Transcatheter options for the treatment of noncalcified aortic regurgitation. JACC Cardiovasc Interv. 2015; 8:1850–1853.

SUPPLEMENTARY MATERIALS

Supplementary Video 1

Pre-procedural echocardiography in parasternal long- and short-axis view. Severe aortic regurgitation with diffuse wall thinning was observed. In short-axis view, a malfunctioning right coronary cusp which mainly contributed to aortic regurgitation was noted.

Supplementary Video 2

An aortogram showed severe aortic regurgitation.

Supplementary Video 3

Successful transcatheter heart valve replacement utilizing the CARVAR outer strip ring as a landing zone.

Supplementary Video 4

Follow-up echocardiography in parasternal long- and short-axis view. No definite evidence of central aortic regurgitation and well-functioning transcatheter heart valve without paravalvular leakage were observed.
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ORCID iDs

Hyungdon Kook
https://orcid.org/0000-0003-1440-0462

Cheol Woong Yu
https://orcid.org/0000-0002-5871-4562

Seung Hun Lee
https://orcid.org/0000-0002-5154-1697

Haim Danenberg
https://orcid.org/0000-0002-1349-9627

Seong-Mi Park
https://orcid.org/0000-0002-6710-685X

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