Journal List > Allergy Asthma Respir Dis > v.6(4) > 1099901

Yoon, Kim, Lee, Bang, Bae, Park, Lee, Jung, Choi, Lee, and Park: Ecthyma gangrenosum and agranulocytosis in a previously healthy 12-month-old girl: Report of 1 case with a literature review

Abstract

Ecthyma gangrenosum (EG) is a rare skin manifestation which starts with a maculopapular eruption and followed by a necrotic ulcer covered with black eschar. EG usually occurs in immunosuppressed patients with Pseudomonas aeruginosa sepsis. We present a pre-viously healthy 12-month-old girl with EG by P. aeruginosa and agranulocytosis due to influenza A and then rhinovirus infection, without bacteremia. It is important for allergists to culture wound and differentiate EG from other skin disorders including Tsutsuga-mushi disease and initiate appropriate empiric antipseudomonal antibiotic treatment, and to evaluate for possible immunodeficiency, even in a healthy child.

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Fig. 1.
A 12-month-old girl had a round shaped skin lesion of a necrotic ulcer with surrounding erythematous rim at the Emergency Department on the 8th day.
aard-6-229f1.tif
Fig. 2.
(A) A black eschar in central area surrounded by erythematous rim reap-peared on the 9th day. Eschar had occurred on the 4th day of skin lesion. (B) A black eschar in central area surrounded by erythematous rim. Picture zoomed in panel A.
aard-6-229f2.tif
Fig. 3.
Surgical debridement was performed on the 5th admission day.
aard-6-229f3.tif
Fig. 4.
Changes in neutrophil count (ANC) by date and then month. GCSF, granulocyte colony stimulating factor; I&D, incision and drainage.
aard-6-229f4.tif
Table 1.
Summary of lab findings
Test Results
Complete blood cell Aganulocytosis
Wound culture Pseudomonas aeruginosa
Blood culture Nagative
Rapid influenza diagnostic tests Influenza A
Multiplex PCR assay from nasopharyngeal aspirates Human rhinovius
Immunoglobulins & complements Normal
Peripheral blood smear Relative lymphocytosis

PCR, polymerase chain reaction.

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