Journal List > Allergy Asthma Respir Dis > v.6(4) > 1099897

Allergy Asthma Respir Dis. 2018 Jul;6(4):206-210. Korean.
Published online July 30, 2018.  https://doi.org/10.4168/aard.2018.6.4.206
© 2018 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology
Correlation of respiratory syncytial virus infection with climate parameters and air pollution levels in Korean children during 2005–2012
Ji-Hyun Jung,1 Shou-Yu Chu,1 Je-Yeon Kim,1 Tae-Hee Han,2 Sang-Hun Park,3 Ju-Young Chung,1 and Hyo-Bin Kim1
1Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
2Department of Diagnostic Laboratory Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea.
3Microbiology Division, Seoul Health Environment Research Center, Seoul, Korea.

Correspondence to: Hyo-Bin Kim. Department of Pediatrics, Inje University Sanggye Paik Hospital, 1342 Dongil-ro, Nowon-gu, Seoul 01757, Korea. Tel: +82-2-950-1663, Fax: +82-2-950-1662, Email: hbkim@paik.ac.kr
Received January 22, 2018; Revised March 14, 2018; Accepted March 26, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/).


Abstract

Purpose

Respiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infection (LRTI) in infants and children. We investigated the association of meteorological conditions and air pollution with the prevalence of RSV infection.

Methods

Between January 2005 and December 2012, a total of 9,113 nasopharyngeal swab specimens from children under 3 years of age who were admitted to the hospital with acute LRTI were tested for RSV antigens using a direct immunofluorescence kit. Meteorological data (mean temperature, precipitation, wind speed, and relative humidity) and air pollutant levels including PM10 (particulate matter with a median aerodynamic diameter less than or equal to 10 µm in diameter), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO) in Seoul during the study period were collected from the national monitoring system. The correlations of the monthly incidence of RSV infection with climate factors and air pollutant levels were analyzed.

Results

RSV infection mainly occurred between October and February, and showed the peak in November. The prevalence of RSV infection had a moderate negative correlation with mean temperature (r=−0.60, P<0.001), a weak negative correlation with relative humidity (r=−0.26, P=0.01), and precipitation (r=−0.34, P=0.001). Regarding air pollutants, RSV activity moderately correlated with NO2 (r=0.40, P<0.001), SO2 (r=0.41, P<0.001), and CO (r=0.58, P<0.001). In the RSV peak season in Korea (between October and February), RSV epidemics showed a weak positive correlation with relative humidity (r=0.35, P=0.03) and precipitation (r=0.38, P=0.02).

Conclusion

Meteorological factors and air pollutant levels may be associated with RSV activity. Therefore, further nationwide large-scaled intensive evaluations to prove factors affecting RSV activity are warranted.

Keywords: Respiratory syncytial virus; Prevalence; Climate factors; Air pollution

Figures


Fig. 1
Monthly distribution of respiratory syncytial virus (RSV) infection, climate factors, and air pollutant levels from 2005 to 2012. PM10, particulate matter with a median aerodynamic diameter less than or equal to 10 µm in diameter; NO2, nitrogen dioxide; SO2, sulfur dioxide; CO, carbon monoxide.
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Tables


Table 1
Distribution of respiratory syncytial virus prevalence at each year and month
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Table 2
Correlation of respiratory syncytial virus prevalence with climate factors and air pollutants
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